Excited and proud to see the main work from my PhD and postdoc on the development of "GLP-1 directed NMDA receptor antagonism for obesity treatment" out in nature today! nature.com/articles/s4158… 1/7 🧵

Now out in its final, edited, version. onlinelibrary.wiley.com/doi/full/10.10…

Large Libraries of Structurally Diverse Macrocycles Suitable for Membrane Permeation (Christian Heinis and co-workers) Alexander L. Nielsen EPFL Chemistry #openaccess onlinelibrary.wiley.com/doi/10.1002/an…

Become our future colleague! 🇩🇰Extensive display-experience required. careers.novonordisk.com/job/M%C3%A5l%C…

Very excited for this consortium!

Here is the job posting to join the Heinis lab as a PhD student in this consortium:(epfl.ch/labs/lppt/wp-c…) #PhDposition

We are looking for a new Department Manager in Research Chemistry. 🇩🇰🧑‍🔬 #chemjobs novonordisk.com/content/nncorp…

Small N-terminal macrocycle with a D-amino acid can stabilize alpha-helices. RaPID doesn't just generate new individual molecules, it can also summon up intriguing chemical motifs. Now out in JACS: pubs.acs.org/doi/10.1021/ja… @fabian_hink David de Sancho Novo Nordisk Foundation UCPH Healthscience

It was a pleasure to host this year’s Novo Nordisk Chemist of the Future Symposium. Such a high level of talks from the invited and talented PhD students/postdocs in chemistry. Thanks for some wonderful days of science!

I am really excited to share our latest #sirtuin research on bioRxiv! We used mechanism-based crosslinking to solve the structure of SIRT7 and its interaction with biological substrates on the nucleosome. More details to follow 🙂

Are you looking for a PhD position in peptide synthesis, automation, and computational analysis? 🧪 💊💻 We have an open position for a collaborative PhD thesis (with Novo Nordisk). For more details, please see: jobs.uzh.ch/job-vacancies/… ⏰ Application deadline = November 15

Very excited for this collaboration with Nina Hartrampf for which we are looking to fill a PhD position in the Hartrampf group at the University of Zürich with research visits to Novo Nordisk in Denmark! More information here: jobs.uzh.ch/job-vacancies/…

Exciting paper from my colleagues at Novo Nordisk. Just published in @nature! nature.com/articles/s4158…

One of my last posts before migrating to 🔵☁️ But can't help but share this amazing work by my colleagues. Now out in Nature Comms! nature.com/articles/s4146…

Happy to share the latest preprint from my PhD studies on the discovery of de novo macrocyclic inhibitors of HDAC11. This was a great collaboration between @christianaolsen lab (@carlosmyruela, Thomas Hansen) and Christian Heinis lab (@alexanderln).

The macrocycle is therefore fully validated as a potent, selective and cell-permeable probe of HDAC11. We hope that it can shed some light on HDAC11 biology of which we still understand very little. Huge thanks to all the co-authors, this project was a great collaborative effort.

We have two fully funded PhD opportunities in medicinal chemistry and chemical biology through the EASTBIO BBSRC DTP. Deadline 17th Jan 25 More details and apply below findaphd.com/phds/project/e…   findaphd.com/phds/project/e…