Getting in shape #wearefamily

It has been an absolute #joy to have Aletta van den Bosch doing her master with us. Sad to see her leaving now but sure we’ll hear again from her soon #Pluchino lab #WeAreFamily

Congratulations 🏆 Aletta van den Bosch Aletta van den Bosch (NIN) for winning the grad student poster prize at GRC #Myelin Meeting Gordon Research Conferences for the poster titled: “Ultrastructural abnormalities in the normal appearing white matter in MS driven by immune activity”!

Quinty Bisseling, MSc Aletta van den Bosch Rogier Min (: Anaïs :)

Thank you all for a wonderful #ONWAR22 annual PhD meeting in the lovely Woudschoten. See you next year!

New publication!✨ We show that in MS normal appearing white matter the axon-myelin unit is altered and there is less compact myelin wrapping, which may predispose the tissue for lesion formation. Read it here! onlinelibrary.wiley.com/doi/epdf/10.10…

Patiënten met MS laten structurele afwijkingen zien in hun witte stof, nog voor er MS-ontstekingen ontstaan. Dit blijkt uit een nieuwe studie van het Nederlands Herseninstituut en het Max Planck Instituut. Lees meer: herseninstituut.nl/nieuws/witte-s…

🚨New study from @MironLab (UK DRI at Edinburgh) reveals an important role for the star-shaped brain cells astrocytes in repairing myelin, the protective coating around neurons. This could have important consequences in MS, Alzheimer's & other conditions👉buff.ly/44fP2uI

📸Group photo with all the participants of the #Cajal course on #Glial cells in #Health and #disease The CAJAL Advanced Neuroscience Training Programme @staci_bilbo Thora Karadottir Lab Cagla Eroglu Jean Christ Delpech Thomas Papouin (Papouin Lab - WashU)

#Scientists identify the first #genetic marker for #MS severity, opening the door to preventing long-term disability.nin.nl/news/what-make…

🎉 Our IMSGC and MultipleMS work on genetic determinants of multiple sclerosis (MS) severity is out in Nature! Read for the main findings of the study, led by myself and co-advised by Sergio Baranzini and Stephen Sawcer. #MS #Genetics 🧬 doi.org/10.1038/s41586…

Our latest preprint, a fantastic & supersynergistic collaboration between @Pkukanja in our lab Karolinska Institutet & Christoffer Langseth MatsNilssonLab Stockholm University! biorxiv.org/content/10.110…

📸Group photo with with the instructors of the second block of our #Cajal course on #Glial cells in #Health and #disease The CAJAL Advanced Neuroscience Training Programme

After an exciting three weeks at the #Cajal summerschool on glial cells in health and disease, I am now travelling to Berlin for #Glia2023! Come see me at my poster T16-150C on Monday to talk about microglia nodules and lesion formation in multiple sclerosis.

Thanks to everybody who came to visit me at my poster at #Glia2023, it was a great session! If you missed it, read all about microglia nodules and MS lesion formation in our preprint: biorxiv.org/content/10.110…

Publication alert! 🙌 Our research delves into the intricate mechanisms behind MS lesion formation, focusing on microglia nodules. We show that microglia nodules can form 'mini-lesions'. Read all about it here: nature.com/articles/s4146… Huge thanks to everybody who contributed!

Interested in how heterogenous MS is, and how different components of MS pathology together drive disease progression? Take a look at our latest publication! link.springer.com/article/10.100…

Publication alert! 🚨 Expression of checkpoint molecules CD200 and CD47 is lower in multiple sclerosis cortex vs controls, and this is correlated with a more exacerbated pathology. This gives insight in mechanisms of disease progression. Read it here: academic.oup.com/braincomms/art…

Pre-print alert! 🎉 In this collaborative project we linked microglial states to lesion expansion and repair in multiple sclerosis human brain tissue, using spatial transcriptomics analysis. Thanks to everybody who contributed! Read about it here: biorxiv.org/content/10.110…

More than just smouldering inflammation. This autopsy study on people with MS found Inflammatory microglia are linked to impaired oligodendrocyte maturation [these are the myelinating cells in the central nervous system] pubmed.ncbi.nlm.nih.gov/39877374/