The searing wordplay in this editorial 💎 on #delirium speaks to my soul 🫠 His nurse calls him ‘pleasantly confused’. As if he could be. The pressure to discharge mounts, and so does the tension between teams. We can all be...less confused by delirium. doi.org/10.1111/acps.1…

Trying out Mastadon and testing to see if I get thrown off twitter for the link (I heard they flip-flopped on banning links to cage us in). Find me here: @[email protected]

Please re-Tweet this reason why hospitals must allow family caregivers to be present when people with #Alzheimers disease and other forms of #dementia are being evaluated or receiving treatment and care.

Dear friends and colleagues from all over the world. My beautiful country suffered from a series of earthquakes with devastating consequences. Please consider donating to humanitarian aid organizations. #TurkeyQuake gofundme.com/f/xh8d5t-turke…

6/8 Because of the known variability of Abeta load in transgenic mouse models of AD we tested the effects of acute & chronic visual flicker, genetic background, sex & age to identify a treatment window. There were no significant changes in Abeta levels in any of these conditions.

Your gift on #1DayforIowa helps fund research into Lewy body and Parkinson's dementia in the Aldridge Lab! givetoiowa.org/lewy Here you see pathological aggregates of a-synuclein (pink) filling a neuron in a person with severe dementia.

Our newest preprint up on biorxiv: biorxiv.org/content/10.110… Data: narayanan.lab.uiowa.edu/article/datase… with Aldridge Lab TLDR: Rodent PD models don't always work as advertised

Gave a talk at #wpc2023 today as a plenary. That’s tiny me in the bottom right corner speaking about co-pathologies.

Excited to get tweeted about! Less excited to spot a typo… maybe this is the European spelling of LC :-) But great visibility for the Smash Dementia! Team. Marcinkiewcz Lab Jacob Simmering @Prof_BBaran

Proud of all we've accomplished this year - and even prouder of the things we've got cooking for the future Aldridge Lab Jacob Simmering

Excited to be an author on this study in JAMA. We're in a new era of detecting neuropathology in living patients! We are already using this in clinic to detect alpha-synuclein (the protein associated w/Parkinson's disease and Lewy Body Dementia) in skin. jamanetwork.com/journals/jama/…

Higher regional alpha-synuclein levels in cortex lead to increased survival of new spines in nearby neurons- We used awake imaging following transduction to track the process! link.springer.com/10.1007/s10571…

The Aldridge lab is representing strong this year! Five posters at #sfn2024. We start tomorrow morning with three posters from our human work. Hope to see you there!

Finally caught Aimee alone for 30 seconds. Lots of people interested in at-home cognitive tasks to track fluctuations. C18.

Our star neurology fellow Kaancan (currently at UCSF) came back to the Midwest to present work on human autopsy co-pathology from our dementia patients. C20

Yiming (post-bac) I couldn’t catch alone because dendritic spines in human tissue are hot! She’s lost her voice with all the talking. C19

Kalpana representing our newly funded work on synuclein in the arousal system and locus coeruleus to study mouse cognitive fluctuations!

Jacob already deep into explaining our lab’s head-fixed STOP task for probing neural activity during timing and behavioral flexibility. U3. #SfN2024

Very concerned! America leads in science in the world because of NIH. He is literally pausing the grant reviews for the research you care about - children with cancer, dementia, you name it - and wasting millions by pausing everything with no warning. science.org/content/articl…

Marco Hefti (a major Aldridge lab collaborator) and I both received impact awards from our students! Yiming in the lab was also awarded a student employee of the year award. Congrats!