Everyone you need to see are here for protein designers.

Impressive work! Congratulations to Adam!

Congratulations to the team Stephen Rettie, David Juergens, Victor Tolulope Adebomi , *RFpeptides* is really cool method for all peptide chemists! Accurate de novo design of high-affinity protein binding macrocycles using deep learning biorxiv.org/content/10.110…

Congratulations to Bingxu Liu Nathan, and Julia Bonzanini ! Great work on developing pMHC binders! Design of high specificity binders for peptide-MHC-I complexes biorxiv.org/content/10.110…

Really cool GPCR binder! Both agonist and antagonist. State-specific Peptide Design Targeting G Protein-coupled Receptors biorxiv.org/content/10.110…

Totally!!!

Totally with Sergey Ovchinnikov. There are medical crisis, wealth gap, …, clearly AI can help, clearly previous US strategy didn’t work, why not let codes return to its original status, be open, be a big friendly community, and focusing on solving real world problems!

Amazing!!!!!

NIH cuts are hitting young scientists the hardest. By David Baker. timmermanreport.com/2025/03/david-…

Any billionaires with no idea what to do w/ their 💰 money? This could be your chance to stop the death of science, technically and innovation in America. Lots of PhD programs are being cancelled or reduced significantly in size across America... 🫣 wbur.org/news/2025/03/1…

New enzymes can unlock chemistry we never had access to before. Here, we introduce RFdiffusion2 (RFD2), a generative model that makes significant strides in de novo enzyme design. Preprint: biorxiv.org/content/10.110… Code: coming soon Animation credit: x.com/ichaydon (1/n)

Harvard will continue to defend against illegal government overreach aimed at stifling research and innovation that make Americans safer and more secure. Read the full statement: hrvd.me/d24cca

Sri Kosuri

Without its international students, Harvard is not Harvard. hrvd.me/IntStudents25t

It’s out! This is the version proved to be pretty powerful for both ligand binder design and enzyme design!

Can protein design empower plant studies and engineering? Come to check out our recent review on Nature. We covered many aspects of *AI4plant* opportunities that are ready to go. nature.com/articles/s4158…

Just turned on my DM function per people’s reminder 😂. Now do DM/email

I’ll be at Houston for recruiting between Aug 13-22, DM and get a coffee chat with me if you’re interested in joining a protein design lab!

Thrilled to announce our new preprint, “Protein Hunter: Exploiting Structure Hallucination within Diffusion for Protein Design,” in collaboration with Griffin, Gaurav Bhardwaj and Sergey Ovchinnikov 🧬Code and notebooks will be released by the end of this week. 🎧Golden- Kpop Demon Hunters