Ajoy Oommen John (@ajoyojohn) 's Twitter Profile
Ajoy Oommen John

@ajoyojohn

Medical Oncology, Christian Medical College, Vellore

ID: 1307221150158786562

calendar_today19-09-2020 07:33:33

180 Tweet

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Rajesh S (@dr_rajeshs) 's Twitter Profile Photo

An intriguing case report published recently CMC Vellore Clusters of Neuromelioidosis 🧠cases in 2023-A deadly brain infection killed 8 people with potential iatrogenic source linked to single dental clinic after invasive dental procedure using repeated same saline&instruments

An intriguing case report published recently <a href="/OffCMCVellore/">CMC Vellore</a> Clusters of Neuromelioidosis 🧠cases in 2023-A deadly brain infection killed 8 people with potential iatrogenic source linked to single dental clinic after invasive dental procedure using repeated same saline&amp;instruments
Stephen V Liu, MD (@stephenvliu) 's Twitter Profile Photo

This is a major story from #ASCO25. Randomized phase 3 trial of time of day of immunotherapy infusion. Randomized to infusion before or after 3pm. Early infusion far superior: PFS 11.3 vs 5.7 HR 0.42, OS HR 0.45! Impactful, pragmatic, not costly. This should be a bigger story.

This is a major story from #ASCO25. Randomized phase 3 trial of time of day of immunotherapy infusion. Randomized to infusion before or after 3pm. Early infusion far superior: PFS 11.3 vs 5.7 HR 0.42, OS HR 0.45! Impactful, pragmatic, not costly. This should be a bigger story.
OncoDaily (@oncodaily) 's Twitter Profile Photo

Praveen Kumar Marimuthu: Best of ASCO 2025 – LMIC version Praveen Kumar Marimuthu oncodaily.com/insight/pravee… #OncoDaily #Oncology #Cancer #Health #Medicine #MedX #MedEd #MedNews #ASCO25 CancerWorld

Praveen Kumar Marimuthu: Best of ASCO 2025 – LMIC version

<a href="/drmpk91/">Praveen Kumar Marimuthu</a> 

oncodaily.com/insight/pravee…

#OncoDaily #Oncology #Cancer #Health #Medicine #MedX #MedEd #MedNews #ASCO25 <a href="/CancerWorldmag/">CancerWorld</a>
Avi Roy (@agingroy) 's Twitter Profile Photo

🧬 The Liquid Biopsy Truth: What $40 Billion in Cancer Screening Really Buys Us A masterful The New Yorker investigation by Siddhartha Mukherjee reveals why finding cancer early isn't what we think it is. Here's what longevity clinics don't tell you... 🧵

🧬 The Liquid Biopsy Truth: What $40 Billion in Cancer Screening Really Buys Us

A masterful <a href="/NewYorker/">The New Yorker</a> investigation by <a href="/DrSidMukherjee/">Siddhartha Mukherjee</a> reveals why finding cancer early isn't what we think it is.

Here's what longevity clinics don't tell you... 🧵
Ajoy Oommen John (@ajoyojohn) 's Twitter Profile Photo

Congratulations Praveen Kumar Marimuthu for your eye opening work! Financial distress is a known problem for Indian cancer patients, but it is rarely measured or accounted for in practice or studies. Integrated targeted referrals improving multi- domain distress is encouraging!

Josh Thomas Georgy (@jtgeorgy) 's Twitter Profile Photo

📢 IMP work from CMC Vellore (Official) & Adyar Cancer Institute (WIA), Chennai, published in BMJ SPCare. 📈 Timely early palliative care referrals rose from 30–37% ➡️ 60–66% via sustainable QI interventions. 📝 Read doi.org/10.1136/spcare… 👏 Congrats Praveen Kumar Marimuthu, Jewell, JENIFER JEBA SUNDARARAJ Ma’am & the team!

📢 IMP work from <a href="/OffCMCVellore/">CMC Vellore (Official)</a> &amp; Adyar <a href="/CI_WIA/">Cancer Institute (WIA), Chennai</a>, published in <a href="/BMJ_SPCare/">BMJ SPCare</a>.
📈 Timely early palliative care referrals rose from 30–37% ➡️ 60–66% via sustainable QI interventions.
📝 Read doi.org/10.1136/spcare…
👏 Congrats <a href="/drmpk91/">Praveen Kumar Marimuthu</a>, Jewell, <a href="/JeniferJeba/">JENIFER JEBA SUNDARARAJ</a> Ma’am &amp; the team!
Dr Amol Akhade (@suyogcancer) 's Twitter Profile Photo

📢 Real-world evidence from Tata Memorial 🇮🇳 In HR+/HER2− metastatic breast cancer, oral chemo-hormonal therapy (capecitabine + hormone therapy) showed encouraging outcomes in a heavily pre-treated cohort (median 3 prior lines): 🧪 Regimens: Capecitabine + • Tamoxifen /

Josh Thomas Georgy (@jtgeorgy) 's Twitter Profile Photo

📢Our new paper CMC Vellore (Official) Pathology, MedOnc out in ecancer doi.org/10.3332/ecance… After Dr. Dr Ullas Batra's report, this is largest Indian series of tepotinib-Rxed METex14 mNSCLC. Led by Ashish Singh, Dr. Rekha Pai Anjana Joel, Dr. Rohini Ajoy Oommen John Dr. Deepa Susan #LCSM

📢Our new paper <a href="/OffCMCVellore/">CMC Vellore (Official)</a> Pathology, MedOnc out in <a href="/ecancer/">ecancer</a> doi.org/10.3332/ecance…
After Dr. <a href="/ullas_batra/">Dr Ullas Batra</a>'s report, this is largest Indian series of tepotinib-Rxed METex14 mNSCLC. Led by <a href="/todrashish/">Ashish Singh</a>, Dr. Rekha Pai <a href="/ajoel_84/">Anjana  Joel</a>, Dr. Rohini <a href="/ajoyojohn/">Ajoy Oommen John</a> Dr. Deepa Susan
#LCSM
Rishabh Jain (@drrishabhonco) 's Twitter Profile Photo

🧬 Why doesn’t 5-FU work in dMMR/MSI-H tumors? 👩‍🔬 Normal cells: 5-FU → DNA mismatches ❌ → MMR proteins (MLH1, MSH2, MSH6, PMS2) keep trying to “fix” → futile repair loops → strand breaks → cell death ☠️ 🧟‍♂️ dMMR tumors: 🚫 No proofreader → mismatches go unnoticed → no

🧬 Why doesn’t 5-FU work in dMMR/MSI-H tumors?

👩‍🔬 Normal cells:
5-FU → DNA mismatches ❌ → MMR proteins (MLH1, MSH2, MSH6, PMS2) keep trying to “fix” → futile repair loops → strand breaks → cell death ☠️

🧟‍♂️ dMMR tumors:
🚫 No proofreader → mismatches go unnoticed → no
Josh Thomas Georgy (@jtgeorgy) 's Twitter Profile Photo

Bloomberg Bloomberg (Global, NY) Robert Langreth recently featured our work from CMC Vellore Medical Oncology & Haematology and Tata Memorial Hospital: low-dose immunotherapy and potential for equitable cancer care. What if 1/6th the dose works just as well? bloomberg.com/features/2025-…

Bloomberg <a href="/business/">Bloomberg</a> (Global, NY) <a href="/RobertLangreth/">Robert Langreth</a> recently featured our work from <a href="/OffCMCVellore/">CMC Vellore</a> Medical Oncology &amp; Haematology and <a href="/TataMemorial/">Tata Memorial Hospital</a>: low-dose immunotherapy and potential for equitable cancer care. What if 1/6th the dose works just as well? 
bloomberg.com/features/2025-…
Zachariah Thomas (@drzachariaht) 's Twitter Profile Photo

Delighted to see this impactful study from CMC Vellore CMC Vellore on low-dose immunotherapy in advanced head and neck cancer gaining broader recognition! Congratulations to Josh Thomas Georgy, Ashish Singh, Ajoy Oommen John and the team back home! nature.com/articles/s4159…

Ashish Singh (@todrashish) 's Twitter Profile Photo

Happy to share our experience... What immunotherapy can achieve in advanced non metastatic HNSCC ? hope this will help our patients in india.. 🇮🇳 ICMR Common Sense Oncology nature.com/articles/s4159…

Josh Thomas Georgy (@jtgeorgy) 's Twitter Profile Photo

🚨Out in Scientific Reports Nature Portfolio our study from CMC Vellore Ashish Singh Low-dose nivolumab + induction chemo in unresectable/loc advanced HNSCC led to 75 % ORR, 31 % conversion to resectability, ~90 % cost reduction. See below 🧵on our findings👇nature.com/articles/s4159…

Anirban Maitra (@aiims1742) 's Twitter Profile Photo

An interesting venue (Cancer Cell!) for this randomized phase 3 trial in #PancreaticCancer. Neoadjuvant nab-paclitaxel plus gemcitabine followed by modified FOLFIRINOX for resectable pancreatic cancer cell.com/cancer-cell/fu… Sequential NAT v upfront surgery in resectable PDAC!

An interesting venue (<a href="/Cancer_Cell/">Cancer Cell</a>!) for this randomized phase 3 trial in #PancreaticCancer. 
Neoadjuvant nab-paclitaxel plus gemcitabine followed by modified FOLFIRINOX for resectable pancreatic cancer
cell.com/cancer-cell/fu…
Sequential NAT v upfront surgery in resectable PDAC!
Praveen Kumar Marimuthu (@drmpk91) 's Twitter Profile Photo

🎓 An absolute honour to graduate from the 1st batch of DM Medical Oncology CMC Vellore alongside an exceptional group of colleagues Ajoy Oommen John Josh Thomas Georgy Harikrishna kovilapu Prashant & our ever-inspiring mentor Ashish Singh Grateful & humbled to be a small part of MONC, CMC 🤍💙

🎓 An absolute honour to graduate from the 1st batch of DM Medical Oncology <a href="/OffCMCVellore/">CMC Vellore</a> alongside an exceptional group of colleagues <a href="/ajoyojohn/">Ajoy Oommen John</a> <a href="/jtgeorgy/">Josh Thomas Georgy</a> <a href="/Harikri44884728/">Harikrishna kovilapu</a> Prashant &amp; our ever-inspiring mentor <a href="/todrashish/">Ashish Singh</a> Grateful &amp; humbled to be a small part of MONC, CMC 🤍💙
ESMO Open (@esmo_open) 's Twitter Profile Photo

Phase II trial of enfortumab vedotin in patients with previously treated gastric and esophageal cancers in ESMO Open. EV shows activity especially in patients with esophageal squamous cell carcinoma, with expected safety profile. esmoopen.com/article/S2059-…

Phase II trial of enfortumab vedotin in patients with previously treated gastric and esophageal cancers in <a href="/ESMO_Open/">ESMO Open</a>. EV shows activity especially in patients with esophageal squamous cell carcinoma, with expected safety profile. esmoopen.com/article/S2059-…