Cyclic Peptides from Graspetide Biosynthesis and Native Chemical Ligation J. Am. Chem. Soc. #Chemistry #Chemed #Science #TechnologyNews #news #technology #AcademicTwitter #AcademicChatter pubs.acs.org/doi/10.1021/ja…

Cyclic Peptides from Graspetide Biosynthesis and Native Chemical Ligation | Journal of the American Chemical Society Princeton University Princeton Engineering Princeton Chemistry #Peptides #Cyclic #Graspeptide #Biosynthesis #NativeChemical #Ligation pubs.acs.org/doi/10.1021/ja…

Thank you to the American Peptide Society American Peptide Society for highlighting our recent work on graspetides that can be morphed into cyclic peptides: americanpeptidesociety.org/aps-news/grasp…. A big shoutout to the lead author on this work Brian Choi who defended his PhD this week!

Early Announcement! simbhq.org/np/ Together with Brad Bradley Moore, Jaclyn Jaclyn M. Winter, and Alessandra Eustaquio Lab, We look forward to welcoming you to the 2025 SIMB Natural Product meeting at San Diego! Keynote speaker Prof. Jennifer Doudna! @doudna_lab

Our chemoenzymatic synthesis of the lasso peptide Microcin J25 is out now in J. Am. Chem. Soc.! We used flow-SPPS to synthesize several sidechain- and backbone-modified precursor peptides and demonstrated their in vitro transformation. pubs.acs.org/doi/10.1021/ja… UZH Chemistry Hartrampf Lab

Excited to be at Boston Bacterial Meeting (BBM) at Boston Univ! Looking forward to some great science #BBM2024 🧫 I’m presenting poster number 104 tomorrow, come say hi!

AlphaFold can't tell you the structure of lasso peptide, a major branch of RiPPs and promising antibiotics. Xingyu wasn't happy about it and decided to create LassoPred. Build your own lasso or download a predicted one: lassopred.accre.vanderbilt.edu. DOI: 10.26434/chemrxiv-2024-q3rn0

Thank you for highlighting our work on the chemoenzymatic synthesis of modified lasso peptides on the covers of J. Am. Chem. Soc.! 🤩 Hartrampf Lab Universität Zürich #peptides

Congrats to Florian Hubrich & Sanath Kandy for this exciting story finally being published. Thanks for the fruitful collaboration with @chekanlab. If you are interested in the chemical space of #RiPP #biosynthetic #enyzmes and #isoprenoids, click here: sciencedirect.com/science/articl…

Cysimiditides: RiPPs with a Zn-tetracysteine motif and aspartimidylation biorxiv.org/cgi/content/sh… #biorxiv_biochem

In a year with so little to cheer about so far, I am happy to share our manuscript on a copper-dependent halogenase. Unbelievable effort by GS Yorick Chiang and Scientist Ph.D Masao Ohashi at UCLA Chem & Biochem UCLA Chemical and Biomolecular Engineering . Thank you to all collaborators and @NIGMS. nature.com/articles/s4158…

Things tend to slow down in winter, but Elsa Ding and Yaoyukun Jiang from our group have engineered a 'cold-adapted' version of a mesophilic amylase. Even with a 45-degree temperature drop, we still observe 30% activity. onlinelibrary.wiley.com/doi/10.1002/an… Angewandte Chemie Vanderbilt Center for Structural Biology

Our first step toward structural prediction of RiPPs: lasso peptide. nature.com/articles/s4146… This tool can be accessed from here: lassopred.accre.vanderbilt.edu Vanderbilt Center for Structural Biology VU Chemical Biology Great working together with A. James Link and Yi-Lei Zhao!

New work from Zhongyue (John) Yang, A. James Link and Yi-Lei Zhao takes a first step toward structural prediction of RiPPs: lasso peptide. nature.com/articles/s4146… Access the tool here: lassopred.accre.vanderbilt.edu