Register for the AACR Virtual Journal Club, May 14 at 2 pm ET! Charles Drake Herbert Irving Comprehensive Cancer Center discusses his paper, "Longitudinal Immune Profiling During Cancer Immunoediting." bit.ly/3tlOwIO

Couldn’t be prouder to have worked with the Drake and Califano teams at Herbert Irving Comprehensive Cancer Center on this project, now out today in Cell. Special shout-out to first authors Aleks,Niv Chowdhury, and Scott Haake, MD, PhD for their hard work! authors.elsevier.com/c/1d5-5L7PXe~U…

How does one define exhaustion? As many have shown with ATACseq (E. John Wherry, Nick Haining, etc.), exhausted T cells are a lineage: posessing a relatively fixed chromatin landscape with unique accessible regions that define them the way Th1 vs Th2 are defined.

In pts with ccRCC, high AXL expression levels in tumour cells is associated high PD-L1 expression, especially in VHL mutated cells, and with lower ORRs and a trend to shorter PFS following second-line anti-PD-1 treatment: clincancerres.aacrjournals.org/content/early/… #kcsm #ImmunoOnc

Online today Cell. By identifying and classifying recurrent immune features, we discovered 12 unique dominant tumor Archetypes that span cancer types. This immune-based classification provides a framework toward understanding tumor immunity to guide immunotherapies 1/n.

A new candidate vaccine against NMIBC in a multi institutional study in close collaboration with Trinity J. Bivalacqua Re-engineered BCG overexpressing cyclic di-AMP augments trained immunity and exhibits improved efficacy against… disq.us/t/457gd6d

Cytoreductive Nephrectomy Following Immune Checkpoint Inhibitor Therapy Is Safe and Facilitates Treatment-free Intervals eu-openscience.europeanurology.com/article/S2666-… Daniel Shapiro Logan Zemp Viraj Master Wade J Sexton Ali Ghasemzadeh, MD, PhD Benjamin Schmeusser Facundo Davaro Surena F Matin MD Philippe spiess E Jason Abel

Online Now: Systematic elucidation and pharmacological targeting of tumor-infiltrating regulatory T cell master regulators dlvr.it/SnDDKT

Results from our Ph2 study using Durva in BCG Unresponsive CIS is online Clinical Cancer Research 👉2/17 CR at 6mo 👉1/17 Gr 3 hepatotoxicity 👉1/17 PD-L1 high pre-treatment doi.org/10.1158/1078-0… #JingsongZhang Wade J Sexton Philippe spiess @sgilbert1973 Julio Pow-Sang #JRCG Moffitt Urologic Oncology Fellowship

Fascinating discovery by @Annaglobig! Exhausted CD8 T cells talk to sympathetic nerves in tissues & tumors. Tex cells express ADRB1 and localize near sympathetic nerves, listening to stress hormone noradrenaline. This promotes their dysfunction. nature.com/articles/s4158…

Platinum-based chemotherapy is the standard of care for previously untreated unresectable or metastatic urothelial carcinoma, w/ cisplatin-based chemotherapy preferred for eligible pts. Full CheckMate 901 trial Research Summary by Michiel van der Heijden et al.: nej.md/3FmKbO6

Online Now: The antitumor activities of anti-CD47 antibodies require Fc-FcγR interactions dlvr.it/Sz5d9R

Enfortumab + Pembro outperforms platinum chemotherapy in advanced UC with a doubling of PFS and a halving of the risk of death @nejm. G3/4 AEs of 56% for EVP vs 70% for chemo & CR=29%. Editorial by @gniegisch ‘EVP is the new standard against which future trials must be compared’

Great job to our UW Urologic Oncology UW Urology students, residents, and fellow presenting their research at Wisconsin urological society meeting. No one moderates better than #MikeRisk

Thrilled to be headed to UrologyMSK for Society of Urologic Oncology fellowship! ari hakimi Couldn’t have done it without the support of all my mentors along the way E Jason Abel Daniel Shapiro Kyle A. Richards DJarrard Mike Risk Tudor Borza

From the March issue: Androgen Receptor Inhibition Increases MHC Class I Expression and Improves Immune Response in Prostate Cancer. brnw.ch/21wRkAK By Lisa Chesner, PhD, Felix Feng, Amy Moran Lab, and colleagues UCSF Helen Diller Family Comprehensive Cancer Ctr OHSU Knight Cancer Institute

NIAGARA’s surgical safety results #EAU25 with Jim Catto. Results show the addition of duvalumab to neoadjuvant platinum chemotherapy did not increase surgical complications or cystectomy rates.

Great job pgy5 Ali Ghasemzadeh, MD, PhD on your poster #AUA25! UW Urologic Oncology Society of Urologic Oncology E Jason Abel

Review Immunity Calico More TOR: The expanding role of mTOR in regulating immune responses cell.com/immunity/fullt…

BREAKING NEWS The 2025 #NobelPrize in Physiology or Medicine has been awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi “for their discoveries concerning peripheral immune tolerance.”