Thrilled to see a piece of my graduate work in PNAS! With Krishnakanth Baratam, Anand Srivastava Soumya Bhattacharyya Thomas Pucadyil; we analyze role of a novel membrane anchor & offer exciting insights into how variable loops in dynamin PH-domain actively facilitate fission! pnas.org/doi/10.1073/pn…

From the ER to outside the cell in 5 minutes - interested in visualizing membrane trafficking in live animals? Check out new paper Developmental Cell authors.elsevier.com/a/1gsqZ5Sx5gtw… Congrats to @CarolinaCamelo6, Raphael Schleutker, @theajacobs_, Dominique Förster + twitterless colleagues @WWU_Muenster

A tour the force of #geneediting and #STED. We have followed up on some of these findings and have 2 papers that will drop soon! looking at endogenous proteins at high resolution in their own unperturbed cellular environment is helping to reveal important trafficking mechanisms!

Our work about superPLD is now published! In this paper, we describe how we can harness mammalian cell-based directed evolution to engineer a membrane editor (phospholipase D; PLD) with superior performance in mammalian cells. 1/n nature.com/articles/s4155…

1/2 Our stressed-out PhD scholars deserve a long-overdue increase in their stipends. The revision was due in 2022 after an already delayed raise in 2019. How can they meet their daily needs & undertake research amid rising inflation? DSTIndia indiatoday.in/education-toda…

New on BioRxiv: Adhesion energy controls lipid-binding mediated endocytosis. A group effort lead by Raluca Groza with contributions from our friends @taraskalab Dimova Lab now at @DimovaLab.bsky.social Claudia Matthaeus and Thomas Weikl Max Planck Institute of Colloids and Interfaces Biochemistry FU Berlin Freie Universität biorxiv.org/content/10.110…

TransitID is out today in Cell! This is a proximity labeling method for unbiased discovery of endogenous proteins that traffick from a defined “source” location to a defined “destination” location. TransitID uses sequential labeling by TurboID in the source, followed by a chase

Happy to share with you, our piece on how the molecular membrane fission machine - dynamin is regulated by 'gears' in its membrane binding PH-domain. Thomas Pucadyil and I curated this brief review for Current Opinion in Cell Biology. Now online: authors.elsevier.com/c/1hPJK3PA3sV0…

Collagen transport through inter-compartmental tunnels! Our theoretical model, led by the Pincet group @LP_ENS_, for how molecular gradients between organelles drive cargo transport through a tunnel - even without a cargo receptor. biorxiv.org/content/10.110…

How can lysosomes, when ruptured, maintain stability allowing for repair? Glad to share nature nature.com/articles/s4158… the function of stress granules (SG) as molecular plugs that stabilise damaged membranes The Francis Crick Institute Max Gutierrez #condensates #lysosomes #TB👇Thread

Our biophysical model in PNASNews! ER export of collagen driven by a mechanochemical ratchet formed by expansion-contraction of intrinsically disordered regions (IDRs) of TANGO1, and gradients of pH/HSP47. IDR “breathing” produces work with each breath. pnas.org/doi/10.1073/pn…

Our paper 'Analyzing the use of metaphors in news editorials for political framing' got accepted at the NAACL mains! Congratulations to all the co-authors Roxanne El Baff Milad Alshomary and Henning Wachsmuth. LUH-AI TRR 318 Constructing Explainability Webis Group #NLP #NLProc. See you in Mexico!

🙌🏿 Congratulations to Vivek Malhotra on his election to the American Academy of Arts and Sciences American Academy of Arts & Sciences Dr Malhotra, group leader of the Intracellular Compartmentation lab at #CRG, joins a distinguished collection of leaders and professionals across many fields.

Happy to share this mini-review that Thomas Pucadyil and I wrote for Biochemical Society Transactions. portlandpress.com/biochemsoctran…

1/n My postdoc work on the evolution of mitosis in Ichthyosporea Gautam Dey Omaya Dudin🍉¦ 🦠¦🔬¦ @SchwabYannick groups is out nature shorturl.at/KPRQw Art by Nirupa Rao contrast fungal-like closed with animal-like open mitosis. Why do cells carry out mitosis in different ways?

#FluorescenceFriday #cellbiology #bioart Three examples of mitochondrial remodeling by lysosomes/late endosomes actively transported along microtubules, as seen by grazing incidence structured illumination microscopy at 1-2 frames/sec. doi.org/10.1016/j.cell…

Great Viewpoint from Vivek Malhotra Journal of Cell Biology! COPII proteins, essential for cargo export from the ER, form not only coated small vesicles but also collars at tubule necks and phase-separate into liquid-like condensates, adapting to physiological demand. rupress.org/jcb/article/22…

Excited to see out in nature my postdoc work! “Membrane prewetting by #condensates promotes tight junction belt formation” How do #tightjunctions form a belt in #epithelia sealing our body cavities? Alf Honigmann MPI-CBG Dresden Biotechnology Center (BIOTEC) of TU Dresden w/ #Jülicher MPI-PKS Dresden doi.org/10.1038/s41586…