Come find out about our research into frontotemporal dementia at this free event at #UCL today! Free to attend & lots of interactive activities. Everyone welcome! eventbrite.co.uk/e/alzheimers-r…

Our new paper: mutant CHMP2B alters neuronal endolysosome trafficking which is rescued by TMEM106B ASOs! doi.org/10.1093/brain/… Brain UK Dementia Research Institute

Congratulations to the two new doctors in the lab - Jack Humphrey and Dr Lauren Gittings. Both have passed their PhD vivas this month! 🎉🍾📚🧠

Our new paper by @MoensT shows C9orf72 repeat-mediated translational repression and toxicity are rescued by EIF1A rdcu.be/bfe3g UK Dementia Research Institute

The Isaacs lab celebrating the diversity in the lab with our first International Lunch at the UK Dementia Research Institute Featuring Spanish croquettes, Italian carbonara, Indian chutney, Swedish potato salad, Hungarian stew, English sausage rolls & German kaiserschmarrn!😋 🤤

Super happy to see my first, first author paper in print! 🎉👩🏻‍🔬🙌🏼Thanks to ⁦Lashley Lab⁩ , ⁦Adrian Isaacs Lab⁩ and Tammaryn Lashley⁩ actaneurocomms.biomedcentral.com/articles/10.11…

Now on bioRxiv: "FUS ALS-causative mutations impact FUS autoregulation and the processing of RNA-binding proteins through intron retention” biorxiv.org/content/10.110… Thanks to everyone in pietro fratta, Adrian Isaacs Lab, Vincent , Marc-David Ruepp and Irene Bozzoni labs.

Congratulations to Dr Jack Humphrey and Dr Dr Lauren Gittings who graduated today! Past students of the Isaacs lab 🎓🍾

Nice preview by Katie Wilson

C9orf72 polyGR is another FTD/ALS-linked protein whose phase separation is altered by arginine methylation - and levels in brain correlate with disease duration - just out in print and great work from Dr Lauren Gittings and @BoeynaemsSteven link.springer.com/article/10.100…

Our latest paper shows a novel role for insulin signalling in C9orf72FTD/ALS elifesciences.org/articles/58565 great work from @AtilanoMagda UK Dementia Research Institute UCL Queen Square Institute of Neurology

New preprint on developing a sensitive Simoa-based CSF biomarker for C9orf72FTD/ALS great collaboration with FTDtalk GENFI Jon Rohrer Wave Life Sciences Dr Amanda led by Katie Wilson and Eszter Katona medrxiv.org/content/10.110…

NEWS: Researchers led by Prof Adrian Isaacs (Adrian Isaacs, UK DRI at UCL) have developed a biomarker to track the success of therapies targeting the most common genetic cause of frontotemporal dementia & amyotrophic lateral sclerosis 🧬 Read more 👉 bit.ly/38kU420

Genome-wide RNA binding analysis of C9orf72 poly(PR) dipeptides, excited for this preprint with ule_lab & Adrian Isaacs Lab to be out! biorxiv.org/content/10.110…

Our new preprint identifies genome wide the RNAs bound by C9orf72 polyPR a great collaboration with ule_lab and ShorterLab led by Rubika Balendra UK Dementia Research Institute biorxiv.org/content/10.110…

Really excited about our latest preprint, where we uncovered a neuroprotective role for neuronal polyunsaturated fatty acids in FTD and ALS. Led by Ashling Giblin and Alex Cammack biorxiv.org/cgi/content/sh… 1/9

After failure of ASO trials targeting C9orf72 sense repeats also targeting antisense repeats is now vital. Our new preprint shows a potential approach using CRISPR-CasRx UK Dementia Research Institute UCL Queen Square Institute of Neurology Alex Cammack biorxiv.org/content/10.110…

Delighted to see our study led by Carmelo Milioto revealing a neuroprotective ECM signature in C9FTD/ALS published! Thanks to MND Association UK Dementia Research Institute and many others! nature.com/articles/s4159…

Our open access opinion in Brain on the disappointing C9 ASO trials and next steps to deliver an effective treatment for C9ALS/FTD co-written with Alex Cammack Rubika Balendra UK Dementia Research Institute UCL Queen Square Institute of Neurology academic.oup.com/brain/article/…

Go Yash!! Yash