The bioRxiv site appears to be linking to a different paper at the moment, so here is a link to the PDF: evodesign.org/Semantic_Minin…

Excited to share our joint work with Richard Shuai, Full-Atom MPNN (FAMPNN), a protein sequence design method that explicitly models both sequence and side-chain structure! 🧵 1/N

We trained a genomic language model on all observed evolution, which we are calling Evo 2. The model achieves an unprecedented breadth in capabilities, enabling prediction and design tasks from molecular to genome scale and across all three domains of life.

Thrilled to see Evo 2 out. We trained a model across DNA from all domains of life, enabling mutation scoring, sequence embedding, and genome generation. All code, models, and data are available. Great summary thread from Patrick Hsu x.com/pdhsu/status/1…