Ketamine is safer than midazolam! Aside from a mild increase in headache and hypertension (*), ketamine was safer across the board. 46% reported sleep disturbance in midazolam but only 25% in ketamine. And 4 of 30 patients in midazolam group had depression, only 1 did in the

"The report said the EMA often prefers granting conditional approval rather than outright denial for drugs addressing major unmet medical needs, particularly when data show large effect sizes" If I remember correctly, 2 Alzheimer's drugs have EMA approval. Both were amyloid-beta

$avxl down 9% after this piece was published. Adam moves markets

$IBKR CEO: "Our margin balances are at their all-time high. Should there be a sudden dislocation in the market, I would expect that risk taking to decrease. What we like and what we see is that our customers have been trading stock on leverage."

> be a fund manager > send a guy to catalogue jackets salespeople at each b2b saas company wore at conferences > sales people splurge on jackets when deal flow is up, its a discretionary purchase > average jacket price for company is a leading indicator of earnings Cheeky

Showing once again that drug effects are absolutely dwarfed by context in MDD trials. These patients were recruited bc they were in crisis requiring hospitalization. Gradual return to baseline in a stable inpatient setting. How much more could ketamine have even added?

why are there HUNDREDS of 18 year olds in full SUITS, using the most dressed-up, slop-filled language possible? university gone from a place to learn about a subject and the world, to a full-on 4-year recruiting experience with zero regard for academics.

Phone screen time is inversely proportional to my quality of life Resets each day

Stop working on instagram ads, go work on hard problems

Awesome! "We build AI systems to rapidly characterize biological sequences and update medicines in real time". Exactly what we need x.com/aditharun_/sta…

Interesting hypothesis for anktiva (il15 agonist) in cancer treatment, will need to look into data. Immediate thought is that we know il2 boosts nk and t cell counts… but it doesn’t work well / has many adverse effects

Will Q4 $TECX Ph1b topline readout of long-acting relaxin (TX45) in pulmonary hypertension (PH) associated with HFrEF be positive? Alise (CEO $TECX) said in her Morgan Stanley talk that data is to be expected 2H of October. First, by "positive" in this Ph1b I mean two things: 1)

Operation Paperclip allowed the US to gain access to information and scientific minds we otherwise would never have. Friedberg brought this up on The All-In Podcast a few weeks ago and how we should think about doing the same today for scientists from other countries. Excerpt from

My favorite quote from The Technologic Republic is highly relevant to engineers, scientists, and physicians: be multidiscplinary. Study things from different fields and apply them. That's what da Vinci, Gutenberg, and Brunelleschi and others did because they had to.

$NTLA Mcap still 1.7 Billion understand its battleground stock - but also been around #Biotechs to know also this is very serious safety issue & FDA will not be happy for condition that’s being well served currently. Ask any Big Pharma about today’s event they know how serious

Stock falls ~50% and I would be panicked if I was a casual investor who opened a position after minimal diligence and reading some posts on this app. Making an informed choice, having and exit and entry plan, position sizing plan, ability to articulate in detail the other

Who makes $NTLA's LNP? Is it Novartis? I believe MoA of LNP is via ApoE on hepatocytes for ATTR programs

Recap of $NTLA call Oct 27, 2025: Male patient with ATTR-CM given dose of $NTLA gene therapy on Sep 30, 2025. AST and ALT > 3 times upper limit of normal and bilirubin > 2 times upper limit of normal. Voluntary pause. Not mandated by FDA. Patient complained of abdominal pain

We have decently good ATTR treatments that do not carry grade 4 ast/alt/bili increase. This opportunity cost is key when thinking about NTLA’s treatment. If there was no treatment available and this was the only one, then different story. Even more different of a story if there