perhaps in a year the single cell field will discover the log function, batch sizes that are a factor of 4, and that scaling laws have a parameter count term. we're so early you can't even believe it

in a world of comodditized labor-replacing AI and resulting indefinite optimism, agency becomes the thing in shortest supply. the returns to human capital accumulation and application by those with creativity and ambition will only increase. you are not a lottery ticket

virtual cells are currently bottlenecked by compute, not novel data: drug discovery is an iterative search process (design, test, analyze) through therapeutic design space guided by a dynamics model directly trawling this therapeutic space with large hypothesis-free

We are super excited to share our seminar schedule for the next few months - join us at Stanford campus to learn about the latest in AI + Biomedicine! Anyone is welcome! snap.stanford.edu/ai-bio-seminar/

yapping continues to be an underrated career strategy (the occasional reference or two helps as well)

tfw you actually simulate 500 million years of evolution in silico by teaching your pretrained virtual cell to self-organize into stable multicellular systems using RL against the ultimate verifiable reward—survival—thereby regularizing it to better match the evolutionarily

just one more striped hyena block bro, I promise. DNA is all you need dog, trust me. the only thing we're missing is ring attention, I swear. once we have the context length to capture long-range interactions we'll solve mammalian genome modeling. yeah yeah I know the human

We are excited to have Adam Green to join us next Tuesday. Adam is the founder at Markov Bioscience and he has deep insights into virtual cell models, mechanistic interpretability and so on. Join us next Tuesday 2:30PM at Gates 415!

if only there were a system that could generate truly novel therapeutic hypotheses not found in the literature, elucidate their mechanism, and use inference-time compute to iteratively optimize candidate molecules to cause any desired delta in biological state...

We're bringing on a guest who I've wanted to have on for a long time — the one and only owl (in SF june 16th-27th), joining me and Andrew Dunn. See you here at noon! youtube.com/live/S2AQ1mFhT…

building a useful virtual cell is a scale and skill (and vision) issue. others have still not yet internalized this and it shows. exciting open-source developments on this front coming from Markov in the next few weeks

the brown m&m test of virtual cell papers: do you explicitly compute loss on observed zeros