Hi folks, we have new faculty open search in Dana-Farber Division of Population Sciences Dana-Farber Harvard Medical School, seeking folks interested in launching an independent research program across our very diverse and interdisciplinary set interests! See link for more info: careercenter.asco.org/job/7622758/as…

We are excited to award the 2024 Basser Global Prize to Patrick Sung, DPhil, of @UTHealthSAMDA for his cutting-edge work in the field of DNA damage repair. He will give the keynote address at our Scientific Symposium in April 2025: spr.ly/6019qQeTU The Sung Lab at UTHSCSA ⁩

At our annual Symposium & Awards Luncheon, Dr. Judy Garber will receive BCRF's highest scientific honor: the Jill Rose Award for Scientific Excellence in recognition of her outstanding contributions not only to BCRF but to the entire breast cancer field. bit.ly/3BVYCdo

Join us in beautiful Ventura for the 2025 GRC meeting Mammalian DNA Repair: Fundamental Mechanisms to Human Biology grc.org/mammalian-dna-…… Great program, including keynotes from David Pellman and Maria Jasin. Many talks and poster slots still available. Apply soon!

Me, when the journal returns the revised paper for failing the technical check (for the third time) after they ask to change the order of the subheadings in the methods - back to how it was when it ‘failed’ the first check!

My corner of the universe circa 1992.

Come and see the poster from the lab #AACR2024 presented by the brilliant Samuel Brito on RECQL4 variants!

When people say: 'views are my own', does it mean no one else can have them?

Our latest paper with Joan JOAN BRUGGE is now out Orli Bahcall! We explore hidden mechanisms of BRCA1 hereditary breast cancer using new mouse models, revealing unexpected tumor-like chromatin changes in Brca1-heterozygous normal mammary cells. nature.com/articles/s4158…

Totally glued to Gregory Radick’s phenomenal book - after his fantastic talk at ASHG

INHERITED: a subset of pathogenic variants in BRCA1/2 are low penetrance, imparting only a moderate risk of cancer to carriers. nature.com/articles/s4169…

Finally had some time to make some nice bentos! Trying to avoid slow death by cafeteria food!

Join us tomorrow at Poster Spotlight Session 2!

Mark your calendar: the next Egmond DNA repair meeting will take place in 2026 from April 19 - 24! You can pre-register to receive announcement here: forms.lumc.nl/lumc2/Egmond Registration will open by June 2025.

A dream come true- published in nature Using CRISPR–Cas9, we analyzed the functional effect of >6500 missense Variants of Uncertain Signficance (VUS) lBRCA2, and reclassified >90% of variants as pathogenic, likely pathogenic, benign, or likely benign. This work changes the

Excited to share our latest study in nature! We used a humanized-mouse ES cell model to explore the functional consequences of all possible BRCA2 missense variants. We've clinically classified >6,500 variants and >1,200 reported in ClinVar! Shyam K. Sharan National Cancer Institute

Congratulations Sounak Sahu, Mélissa Galloux, members of our BRCA Variant Analysis Unit National Cancer Institute for this outstanding work. Sincere thanks to our collaborators Drs. Chari, Papaleo, Michailidou and their team members.

Functional evaluation and clinical classification of BRCA2 variants out on Nature This study focuses on the functional characterization and clinical classification of BRCA2 variants, specifically those within exons 15 to 26, which encode a DNA-binding domain commonly associated