A clinical trial design that is often misunderstood is the #NonInferiority clinical trial design. 1/8 #MethodologyMonday

Extent of surgical resection for radiologically subsolid T1N0 invasive lung adenocarcinoma: When is a wedge resection acceptable? Researchers from Fudan University found their conclusion in #JTCVS: doi.org/10.1016/j.jtcv…

Want to model long-term nonlinear trends and temporal autocorrelation in time series data? I've got tips and solutions here: ecogambler.netlify.app/blog/autocorre… #rstats #mgcv #timeseries

In clinical trials, we sometimes undertake #SensitivityAnalysis alongside the main primary analysis. But when should we use them and to what purpose? 1/8 #MethodologyMonday #80

We often talk about #SWATs in trials. But what are they and how/when should they be done 1/7 #MethodologyMonday #83

One of the primary elements that should form part of a well-conducted clinical trial is the statistical analysis plan or #SAP 1/7 #MethodologyMonday #84

Considering patient and public values and preferences is a crucial part of every clinical practice guideline.  Guideline panels should search relevant evidence. GRADE summary of findings tables enhanced understanding of values and preferences evidence. jclinepi.com/article/S0895-…

I updated my post on equivalence tests using {marginaleffects} this morning. If you want to make an argument *FOR* no effect, then you should be using an equivalence test. carlislerainey.com/blog/2023-08-1…

I was reminded this week of the importance of taking care when interpreting subgroup analysis in clinical trials and especially the helpful role the #ICEMAN tool can play in this regard. 1/8 #MethodologyMonday #95

#OTD 1897 Sir Austin Bradford Hill b d 18 Apr 1991) 🇬🇧CBE FRS President Royal Statistical Society 1950, Guy Gold Medal 1953. Called the “world’s leading medical statistician” he pioneered the modern RCTs & "Bradford Hill" criteria for observational studies. /3

New presentation w/video on #clinicaltrial design and analysis methods for composite outcomes, particularly relevant for rare diseases: fharrell.com/talk/cons @vandy_biostat #Statistics

Excited about and proud of this paper, and thrilled to read all the others in this special issue! psycnet.apa.org/PsycARTICLES/j…

What if we taught #psychstats showing there is only one test, per Allen Downey: allendowney.blogspot.com/2011/05/there-… Using the {infer} #rstats package: infer.tidymodels.org/articles/infer… Or at least leveraging #dataviz to illustrate its all OLS like Jonas K. Lindeløv’s post here: lindeloev.github.io/tests-as-linea…

We all have a role to play to increase support for grad students and postdocs. ➡️ 20 years of choices have created a underfunded system leaving our next gen vulnerable. Out today in Canadian Science Publishing: cdnsciencepub.com/doi/full/10.11… Co-authored by: Thomas Bailey and Fabian CSMB-SCBM Trainees

I can't remember the last time I renamed variables manually in #rstats. I always use my data dictionary for renaming! That way, if I ever need to update names in the future, I'm only updating once in my data dictionary, not in both my data dictionary and script. 🙌

Want to learn about cluster randomized trials conducted in low- and middle-income countries? Published open access in BMJ_Open, our review of *800 trials* provides insights into their characteristics and adherence to reporting requirements. bmjopen.bmj.com/content/14/9/e…

This week in the #MethodologyMonday #Rewind series, I am updating my original post on #pragmatic trials with a couple of useful new articles 1/6 #MethodologyMonday #2 #Rewind

I've decided to collect my DiD materials in a single place. psantanna.com/did-resources There, you will find - 14 lectures of my comprehensive DiD course - Shorter lectures/talks I have given on DiD - My DiD R packages - Some DiD checklists - DiD materials from my friends Enjoy!

Curious to see how those periop vs neoadj debates go now that OS is positive for CM816! Excellent news for patients and health care systems! Congrats to the CM816 team brilliantly led by the wonderful ⁦Patrick Forde⁩!!! ⁦IASLC⁩ ⁦AATS⁩ news.bms.com/news/corporate…

This paper has been in the making for so long that eight children across the co-author group were born between the time we started and now! But it is finally out, and you can check it at arxiv.org/pdf/2503.13323