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Macrophages and nociceptor neurons form a sentinel unit around fenestrated capillaries to defend the synovium from circulating immune challenge nature.com/articles/s4159…

Big congrats Zehao Zhang Junyue Wei Zhou and rest of team on this groundbreaking work!

Excited to share my first paper from grad school on the role of leptin during flu infection! As expected, leptin drives a robust antiviral immune response in mice, but we show for the first time that this response is dispensable for viral clearance: jci.org/articles/view/… (1/5)

Everyone says “Today’s PhD students are so accomplished I wouldn’t have gotten in today” as if it’s a good thing. It’s not. There are amazing young scientists out there today. But grad admissions is ignoring wide swaths of them because it’s been infected with the same

🧵1/ How does the brain repair myelin after injury? We mapped the full cellular choreography of white matter repair using snRNA-seq + Slide-seqv2, uncovering a type I interferon-driven glial program that recruits lymphocytes to promote remyelination. biorxiv.org/content/10.110…

Big congrats Zihan Xu on this amazing work!! Excited to see all the biology this wonderful new system will unlock!

Big congrats Andrew Liao !!! Excited to see the future many applications of this very useful tool!!

Combined #preprint and paper alert! Together with Sohrab Shah and Vivian E. Strong, MD, we have been exploring a fundamental paradox of cancer biology: how can the immune response both suppress and facilitate tumorigenesis? (It's a 2-parter!) biorxiv.org/content/10.110…

Part 2 of our combined efforts with Sohrab Shah and Vivian E. Strong, MD to understand immune evasion in gastric cancer describes the work in this preprint, led by Sohrab Salehi and Emily Stroobant in a brilliant collaboration: biorxiv.org/content/10.110…

Big congrats Zehao Zhang Alex Epstein Chloe Schaefer on this fantastic work!

#Preprint alert! Kevin (Yan-Ting) Chen, a brilliant GSK Graduate School graduate student and NCI F99/K00 awardee, identifies a novel, post-transcriptional checkpoint on intratumoral T cell function: biorxiv.org/content/10.110…

#Preprint alert! Pioneering work by Tanmana Mitra sheds new insights into why T cells become metabolically exhausted during persistent antigen encounter: biorxiv.org/content/10.110…

Big congrats Ziyu Lu and Junyue on this huge milestone ! Very excited to see the impact on aging field this work will provide!

Yet more brilliance from Chrysothemis Brown - its been a joy to have a front-row seat watching her group essentially rewrite the textbook on early life immunity. Kudos to one of the best scientists and human beings that I am fortuate to know! science.org/doi/10.1126/sc…

A tour de force overview of aging associated cell states and their potential for combating aging associated diseases. Congrats Wei Zhou Junyue !

The peer-reviewed version of expansion in situ genome sequencing is now out in Science! The news is bittersweet – when we first revealed this last September, I never guessed it would be my final paper in academia, but a lot has changed. A few parting thoughts:

Identification of the velum interpositum as a meningeal-CNS route for myeloid cell trafficking into the brain: Neuron cell.com/neuron/fulltex…

Congrats Le Wang on this amazing work!

On-demand microglia deliver the therapeutic payload in Alzheimer’s disease. Cell Stem Cell cell.com/cell-stem-cell…