
James Laboratory
@aaronwjames_lab
Researching skeletal development, repair, and neoplasia @JohnsHopkins. BST Pathologist @JHUPath.
ID: 880780586629156864
http://labs.pathology.jhu.edu/james/ 30-06-2017 13:30:30
328 Tweet
547 Followers
606 Following




Fixing cell energy centers through the SIRT3–PINK1–PKM2 pathway helps protect joints and improve movement in osteoarthritis by removing damaged parts and helping cells produce energy!🧐 #cell #osteoarthritis #bone Bone Research_Editorial Office nature.com/articles/s4141…



IGF2BP3 protein's role in promoting rheumatoid arthritis is revealed in a new study, suggesting it could be a target for future treatments.🧐 #protein #bone Bone Research_Editorial Office nature.com/articles/s4141…


Spatial transcriptomics is transforming musculoskeletal research by mapping gene expression in tissue context, offering insights into development and disease!🧐 #gene #tissue #bone Bone Research_Editorial Office nature.com/articles/s4141…



James Laboratory Excited to present our work on how sensory neurons regulate osteosarcoma progression at FACTOR 2025 in Salt Lake City Grand America Hotel Grateful to be part of this inspiring community #MIBAgents #osteosarcoma #SaltLakeCity

Sharing a new study James Laboratory! We report—for the first time—that diabetic neuropathy affects the bone periosteum, ~70% sensory nerve loss. This disrupts bone structure, but restoring nerve signals helps! pubmed.ncbi.nlm.nih.gov/40615376/ Johns Hopkins Pathology NIH Merkin PNNR Center Bone Research

🚨 New paper alert from the James Laboratory! 🦴 Fascinating work uncovering neuron-to-bone crosstalk under high fat diet conditions. Published in Bone Research_Editorial Office A big step forward in understanding how metabolic state shapes skeletal health. Check it out! 📈👏 #BoneBiology

Based on a mouse model, Masnsen Cherief James Laboratory explore how a high-fat diet causes nerve damage and weaker bones, suggesting diabetes disrupts nerve-to-bone signals and affecting bone health in type 2 diabetes!👇 #bone #diet #diabetes Bone Research_Editorial Office







Schwann cells in peripheral nerves help bone healing by transforming into MSCs, which aid bone growth and blood vessel repair. This process is driven by Shh signaling. This discovery could enhance bone regeneration in aging or disease.🥳 #nerves #cell #bone Bone Research_Editorial Office


