Keytruda combined with SBRT was associated with higher rates of adverse events (AEs), including AEs leading to death, compared with SBRT and placebo. #radonc finance.yahoo.com/news/merck-pul…

Detecting a deadly disease early can mean more lives saved and less toxicity! Check out how Aadel Chaudhuri, MD PhD + team are helping us get there!

#ScienceSaturday The combination of anti-CTLA-4 and anti-PD-1 antibodies is FDA approved for the treatment of advanced #melanoma. How does this combination work mechanistically? In a recently published study in Cancer Cell using both single cell TCR and RNA sequencing, Wang

Genomic and epigenomic analysis of plasma cell-free DNA identifies stemness features associated with worse survival in lethal prostate cancer Out on Clinical Cancer Research Study investigates metastatic castration-resistant #ProstateCancer (mCRPC) resistant to androgen receptor signaling

Nvidia CEO on how setbacks must be viewed as opportunities to learn and grow

#ProudMentor — I couldn’t be any prouder than I am watching Bruna Pellini, MD fly high in the #ctDNA liquid biopsy field!!

Thank you Clinical & Translational Epidemiology Unit - MGH for the hospitality — Enjoyed meeting the brilliant and vibrant group and sharing our liquid biopsy insights from Mayo Clinic Radiation Oncology Mayo Clinic Comprehensive Cancer Center with you. And really enjoyed a great North End Italian dinner. 😋 Special thx to Dr. Long Nguyen for the invite!

1/ Can #liquidbx detect pre-malignancy & guide intervention to avert cancer before it develops? Our recent NCI Center for Cancer Research -Mayo Clinic-WashU Medicine led collaboration’s Clinical Cancer Research publication (shorturl.at/amWS2) suggests that it can in #neurofibromatosis (NF1). A 🧵:

At one of the most exciting events of the year: Mercy Precision Medicine Summit, in St. Louis! I’ll be delivering the keynote on liquid biopsy — Current use + Future potential + Our precision Onc research Mayo Clinic Radiation Oncology Mayo Clinic Comprehensive Cancer Center. Thank you Gautum Agarwal for the invite!

NTAP was proud to support a publication from one of our #FrancisSCollinsScholars, Dr. Taylor Sundby, MD 🧬, in AACR’s Clinical Cancer Research journal. The article details a cfDNA fragmentomic approach to distinguish between forms of PNST in #NF1. Read more: bit.ly/4gc6FSU #neurofibromatosis

Nice discussion focusing on the Mayo Clinic Platform at the Mercy Precision Med Summit!

Please welcome the talented ⭐️Katie Lee to the Mayo Clinic Comprehensive Cancer Center family! Dr. Lee will be joining our Thoracic + Sarcoma team along Aadel Chaudhuri, MD PhD, Kenneth Merrell, Kenneth Olivier Meng Xu Welliver + all of our other (non-Twitter-using) fantastic faculty!

Sharing an instructive case. Treated isolated liver met single fx SBRT (40Gy). ctDNA 5 days later increased 80 to 1100!! PET 2 wks after negative (tumor gone), & ctDNA 3 wks later <10. Lesson - if checking ctDNA, wait (at least a few wks?) after SBRT. Have others seen this?

Our co-founder, Dr. Samuel Bakhoum’s pioneering work linking #chromosomal_instability (CIN) to #cancer progression forms the backbone of our research strategy which exploits CIN to develop transformative treatments for cancer patients. FierceBiotech: bit.ly/4g8NzgG

Irv used to teach this class Stanford Stem Cell. No homework. When you arrived he would reveal the title of a paper he thought was foundational. The class would have to come up with which experiments would have been required to back up a title like this. Truly great thought exercise!

Metastatic castration - resistant prostate cancer resistant to androgen receptor signaling inhibitors - Advanced Prostate Cancer Consensus Conference oncodaily.com/insight/137531 Clinical Cancer Research Pradeep Chauhan Ramandeep K. Babbra, MD Sydney Caputo Fabrice Lucien, PhD Chad Tang, MD Russell Pachynski Oliver J. Sartor Christopher Maher Aadel Chaudhuri, MD PhD

Indeed, we’re working on the next step with Children's Tumor Fdn & Mayo Clinic Pathology toward translating these findings into the clinic! Truly grateful to Children's Tumor Fdn for all their support. Our recent paper & current translation efforts wouldn’t have been possible without it.

Preparing to give a lecture on physician wellness & professional fulfillment to med students Cleveland Clinic Lerner College of Medicine - here are some useful references 1/

Mayo Clinic Radiation Oncology Kim Corbin Krishan Jethwa Allison Garda Yasamin Sharifzadeh, MD Jessica Burlile Kelsey M. Frechette, M.D. Kimi Chauhan It is always rejuvenating and inspiring spending time with our residents. The pleasure is all mine

Matthew Walker Cleveland Clinic Lerner College of Medicine Absolutely. First it starts with leaders who prioritize the wellness of their physicians, as it promotes engagement, retention, recruitment, & productivity. Here’s a great example: