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I’m in a plane reading about infinity categories to pass the time and I think I want to jump out of it.

Humans are one of the few mammals that have both red and green cones. A stochastic gene regulatory mechanism was the main model in the field. Sarah Hadyniak, PhD in my lab changed the view, finding that retinoic acid controls their spatiotemporal patterning. journals.plos.org/plosbiology/ar…

Excited to share the published version of this in Molecular Biology and Evolution! Elena Romero developed an approach to quantify recombination from longitudinal short read sequencing, and applied it to measure differences in recomb rate in HIV pops with low and high VL. academic.oup.com/mbe/article/41…

The Sea Lamprey may be a monstrous-looking sea creature, but it’s also an incredible organism for studying how the #brain evolved! 🧠 #biology #evodevo Learn more about these #UnordinaryOrganisms: bit.ly/3V5YXyA

Transposons FTW...yet again! The more we discover about these "junk" elements...the more actual gold we find. Super cool findings from Patrick's lab!

In an era of RNA delivery and therapeutics, we sought to “write” RNA molecules directly into messenger RNA to replace disease-causing exons or engineer synthetic proteins Our new work on RESPLICE enables fully programmable and highly efficient (45-90%) transcriptome engineering

E. coli engineered to become stem cells that differentiate! We prevent take-over by mutant stem cells that only self renew - by linking differentiation to an essential function. A new way to engineer stable microbial communities. sciencedirect.com/science/articl…

Just released a BLAST tutorial on sandbox.bio! Learn to align DNA and protein sequences on the command line: ➡️ sandbox.bio/tutorials/blas… This tutorial was adapted from Shawn O' Neil's fantastic book.

New paper from our group: we show that PCR, not sequencing, is the main source of error in bulk and single-cell expts and we correct these experimentally using UMI homoblock design. nature.com/articles/s4159…

Excited to share our recent findings on VEGFR1 autoinhibition. Thanks to Molecular signaling lab Swarnendu Roy Subhankar Chowdhury, soumee, Bipra, Sayar Ghosh Kaustav Ganguly, PhD special thanks to Diptatanu Das, pragya kaul,Prosad Kumar Das (he/him) nature.com/articles/s4146…

only that Fig. 6 actually ends up being Fig. 1 ...

Some drugs increase the #mutation rate of their target #pathogen, raising the concerns they might increase the pathogen’s rate of adaptation. This #PLOSBiology Perspective proposes a four-step process to evaluate the evolutionary safety of new treatments. plos.io/491R2sq

Our work on the origins of second malignancies in children is out in Cancer Discovery IRB Barcelona bbglab Institut de Recerca Sant Joan de Déu doi.org/10.1158/2159-8… 1/16

Growing glowing plants!

#Galactose is an important sugar that can fuel glycolysis, but tracking its metabolic dynamics in vivo is challenging. Sa Kan Yoo describe #GALDAR, a genetically encoded sensor to measure intracellular galactose dynamics in flies #PLOSBiology plos.io/3Vx63iO

A multi-tissue de novo transcriptome assembly and relative gene expression of the vulnerable freshwater salmonid Thymallus ligericus biorxiv.org/cgi/content/sh… #bioRxiv

Unravelling differential Hes1 dynamics during axis elongation of mouse embryos through single-cell tracking biorxiv.org/cgi/content/sh… #bioRxiv

Great to be back in the field doing some Oxford Nanopore eDNA work using our Bento Lab 🧬! This time we’re in Jersey, part of the Convex Seascape Survey, looking for the origins of blue carbon input.

Controlling the forces needed to move around is pretty complicated for soft-bodied organisms. Researchers have implemented a new technique for measuring these crawling forces with nanonewton precision in fruit fly larvae. elifesciences.org/articles/87746…