Sandeep Chivukula (@_sandeep) 's Twitter Profile
Sandeep Chivukula

@_sandeep

interests: human + team perf, leadership, tech, stonks, đŸ—ș, longevity, ✈, & ⛰. @harvardhbs @umich (EE) Work:@google but đŸ”„ takes are mine.

ID: 22821199

linkhttp://blog.sandeepchivukula.com calendar_today04-03-2009 19:35:21

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3,3K Following

rachael đŸ’« (@witty_genstein) 's Twitter Profile Photo

Demo day Replit ⠕ today and all I can say is SaaS is so cooked. The throwaway apps we build every day just to test new agent features would be raising 2-5M pre-seeds 5 years ago. Never been a better time to be a builder.

@levelsio (@levelsio) 's Twitter Profile Photo

This is eerily close to my own hit rate of about 5% If we'd actually be able see the graveyard of 95% of founders, the argument to go all in for 10 years on one startup increasingly makes less sense The odds that you win are miniscule but you do end up wasting the best years of

This is eerily close to my own hit rate of about 5%

If we'd actually be able see the graveyard of 95% of founders, the argument to go all in for 10 years on one startup increasingly makes less sense

The odds that you win are miniscule but you do end up wasting the best years of
Ethan Mollick (@emollick) 's Twitter Profile Photo

I've asked this before, but have yet to receive an answer: For my VC followers, what is your theory of AI/AGI that lets you fund a venture with a 5-9 year exit horizon and feel good that it will not be disrupted by AI? Investment patterns don't match VC talk about AGI timelines.

Nic Conley (@niconley) 's Twitter Profile Photo

this boring business owner tells you exactly how to sell AI to small businesses they don’t care about using “AI” in their biz. All they care about is: > saving money > making things faster & smoother. use accordingly.

this boring business owner tells you exactly how to sell AI to small businesses

they don’t care about using “AI” in their biz.

All they care about is:
> saving money 
> making things faster & smoother.

use accordingly.
Sandeep Chivukula (@_sandeep) 's Twitter Profile Photo

Curious how many days of day this is based on and was this reflective of generally accepted science or did you find personalized findings?

Chris Lovejoy, MD (@chrislovejoy_) 's Twitter Profile Photo

My hot take: The vertical AI products that will win are not the ones with the most sophisticated models or techniques - but those with the best system for incorporating domain expertise. The LLMs in the product need to understand the industry-specific and customer-specific way

My hot take: The vertical AI products that will win are not the ones with the most sophisticated models or techniques - but those with the best system for incorporating domain expertise.

The LLMs in the product need to understand the industry-specific and customer-specific way
signĂŒll (@signulll) 's Twitter Profile Photo

so many people in silicon valley quietly made generational wealth by hopping from startup to startup as early execs or first 50 hires. they skipped the existential risk founders take, no sleeping on couches, no pre product despair just slid in once the core idea was already

signĂŒll (@signulll) 's Twitter Profile Photo

very few people have ever eaten the glass of going from nothing to something. idea → design → build → launch. that full arc. with or without ai, it’s brutal. it breaks your back & your brain. it’s one of the most honest pains there is.

Sandeep Chivukula (@_sandeep) 's Twitter Profile Photo

Diving into agentic frameworks (Looked at Agno and #ADK so far), seems like they instantiate all agents statically upfront. Do any create agents on-demand? Eg- orchestrator that selects and spins up a specialist agent just-in-time for a task. Recs Welcome! #AI

Jeff Morris Jr. (@jmj) 's Twitter Profile Photo

I ran into an investor friend who was summering in California. He ordered a glass of Santa Barbara pinot and told me: “I didn’t drink for a year. Then on New Year’s I woke up and realized how boring my life had become. So I had a few drinks that day, and suddenly life had color

I ran into an investor friend who was summering in California. He ordered a glass of Santa Barbara pinot and told me: “I didn’t drink for a year. Then on New Year’s I woke up and realized how boring my life had become. So I had a few drinks that day, and suddenly life had color
Brandon Luu, MD (@brandonluumd) 's Twitter Profile Photo

If you don’t exercise, just do 3x1 minute bursts of intense movement daily (rush up the stairs, walk briskly, bike hard, etc) In a UK Biobank study, this was associated with a 40% reduction in mortality

If you don’t exercise, just do 3x1 minute bursts of intense movement daily (rush up the stairs, walk briskly, bike hard, etc)

In a UK Biobank study, this was associated with a 40% reduction in mortality
Eric Topol (@erictopol) 's Twitter Profile Photo

Chronic poor sleep quality, inflammation, and accelerating brain aging (BAG=brain age gap) thelancet.com/journals/ebiom


Chronic poor sleep quality, inflammation, and accelerating brain aging (BAG=brain age gap)
thelancet.com/journals/ebiom

The Icahnist (@theicahnist) 's Twitter Profile Photo

Terrifying Reality of 2025 Financial sponsor built a prototype in 2 weeks during diligence on an AI-healthcare company. Prototype outperformed the target’s core product in clinician testing. Deal killed.

Terrifying Reality of 2025

Financial sponsor built a prototype in 2 weeks during diligence on an AI-healthcare company. 

Prototype outperformed the target’s core product in clinician testing. 

Deal killed.
Brandon Luu, MD (@brandonluumd) 's Twitter Profile Photo

4 years of vitamin D supplementation (2000 IU/day) significantly slowed telomere shortening compared to placebo. Telomeres shorten with age and are linked to disease risk, suggesting vitamin D may help counteract biological aging.

4 years of vitamin D supplementation (2000 IU/day) significantly slowed telomere shortening compared to placebo.

Telomeres shorten with age and are linked to disease risk, suggesting vitamin D may help counteract biological aging.
Samuel Hume (@drsamuelbhume) 's Twitter Profile Photo

Pharma has cracked many aspects of cardiovascular prevention: cholesterol, hypertension, obesity, diabetes One area that remains unsolved is chronic, low-level inflammation, but we might not be far off

Pharma has cracked many aspects of cardiovascular prevention: cholesterol, hypertension, obesity, diabetes

One area that remains unsolved is chronic, low-level inflammation, but we might not be far off