Delighted to celebrate our latest publication with A/Prof Sylvie Alonso Sylvie Alonso’s Group  on dendritic cell-targeting of SARS-CoV-2 antigens for durable and protective immunity. A fantastic collaboration between Monash Biomedicine Discovery Institute and NUS. doi.org/10.1016/j.ymth…

Our new study just published in Cell Reports Medicine shows that SARS-CoV-2 vaccine breakthrough infections (BTIs) have a positive effect on T cell responses! 1/8 cell.com/cell-reports-m… Alessandro Sette Alba Grifoni Prof. Shane Crotty P Tertuliano @LJIresearch

1/ Increasing vaccine protection against #COVID. A/Prof Sylvie Alonso’s Group NUS & A/Prof Mireille Monash Biomedicine Discovery Institute have discovered a technique for prolonging immune response to #SARSCoV2 virus in pre-clinical models using an antibody construct. More: bit.ly/3yKN3Ek

nature.com/articles/s4142… Happy to share our paper on Tfh specialization in antibody production on type-1 (virus) and type-2 immune responses (parasites, allergy). 1/11 #Tfhcells #germinalcentre #antibodies #immunology #bioinformatics. Legal @imm @fmul Filipa Ramalhete Luis Graca

Loving the versatility of LNP technology. Hmmm, tying to my own work, how about conjugating the Clec9A mAb onto the LNP to deliver antigenic mRNA into cDC1? 🤔

REVIEW Immunity Antibody modulation of B cell responses—Incorporating positive and negative feedback cell.com/immunity/fullt…

Check out our latest preview article in Cell Cell led by Mike Mitchell PhD students roro + Hannah Yamagata on Kedzierska Lab's work identifying OLAH as a key enzyme that drives COVID-19 and other respiratory viral infections! Paper: cell.com/cell/fulltext/…

Very interesting read elucidating why the mRNA (and potentially other platforms) COVID-19 vaxx faces waning nAb. Which begs the qn, how do we design vaxx that promote LLPC generation and seeding?

Happy to share our latest work by Yexin Yang et al. on antibody-mediated control of endogenous retroviruses in mice. In the process, we found “natural antibodies” with broad reactivity against enveloped viruses. Here is how “panviral” antibodies work 🧵(1/) science.org/doi/10.1126/sc…

Excuse to go Japan? 🤭

3 days of hardcore B cells. Learnt alot from new research findings and the insightful scientific discussions during oral and poster sessions. Great experience and looking forward to more B cell science in future. 🤗 Thanks Keystone Symposia for the amazing organizartion. #KSBcells25

#Immunology out now Science Magazine After initial priming in the lymph nodes, mouse CD8 T cells undergo a second phase of stable interactions with dendritic cells that can preferentially stimulate those with a high-affinity for antigen. buff.ly/lCPsea3 By Jobinet al.