NR4A2 & RGS16 promoters support delivery of cytokines (e.g. IL-12) directly to the tumor site, leading to enhanced antitumor efficacy and long-term survival of mice in both syngeneic and xenogeneic models nature A/Prof Paul Beavis Amanda Chen Emily Derrick nature.com/articles/s4158…

Delighted to share our new approach to enhance CAR T cell function in solid tumours published today nature. In this work we identify a new strategy to generate armoured CAR T cells. nature.com/articles/s4158…

Fresh off the press! ♨️ Scientists, including Amanda Chen & Prof Paul Beavis, developed a #CRISPR knock-in strategy that leverages the regulatory mechanisms of endogenous genes to drive transgene expression in a tumor-localized manner. @nature | go.nature.com/3I8Nk8S

In the news today: Peter Mac scientists have developed “Precision Guided Munition” CAR T-cells – smart immune cells that target solid tumours directly. In lab models, they wiped out breast, colon & ovarian tumours with cure rates near 100%! More: petermac.org/about-us/news-…

Dedicating my first post on X to share some exciting news — our work is out today in nature! 🎉 Co-first authored with the amazing lab buddy Amanda Chen, and guided by our incredible supervisors A/Prof Paul Beavis, Phil & Imran. nature.com/articles/s4158…

CAR T cells are engineered to drive tumor-restricted expression of proinflammatory cytokines by repurposing endogenous gene regulatory mechanisms nature.com/articles/s4158… #NBThighlight

Wow. Endogenous regulatory circuit-generated armoured CAR T cells. Seriously cool. Basic premise is to “armour” CAR T cells by getting them to express pro-inflammatory cytokines only when in tumours. Since T cells in tumours get exhausted and up-regulate PD1, the first approach

Wow amazing work using NR4A2/RGS16 promoters to trigger IL‑12/IL‑2 only in tumors is brilliant! A big game‑changer in CAR‑T therapy. Huge congrats to Amanda Chen and colleagues ! 🎉

Pleased to present the latest work from the lab published in Nature Communications in work led by Kevin Sek: nature.com/articles/s4146…

Happy to share a new study led by all-star team Amanda Chen, Kah Min Yap, Imran, Phil Darcy and Prof Paul Beavis showing that tumor site-specific delivery of potent cytokines is a safe way to boost CAR T cell treatment against solid cancers! nature.com/articles/s4158…

Nature research paper: Rewiring endogenous genes in CAR T cells for tumour-restricted payload delivery go.nature.com/4le7GMB

🛡️ Drs. @_AmandaChen, Kah Min Yap, Imran House, Phillip Darcy, and @PaulBeavis4 developed #CRISPR-edited armored CAR T cells that deliver cytokines directly to tumor sites. nature article: go.nature.com/3I8Nk8S Discussion: bit.ly/3Gu9UIF