In our latest work, we show that the GABA shunt pathway maintains redox homeostasis in blood progenitors by coordinating ROS generation with its scavenging. Metabolism and Development Lab Bindley Bioscience Center

Ever wondered what drives hematopoietic stem cell (HSC) heterogeneity? In this preprint, our collaborative team uncovered that differences in HSC reconstitution kinetics play a key role in shaping stem cell heterogeneity and lineage biases. doi.org/10.1101/2025.0… (1/2)

🚨 The Ghersi Lab is Hiring! 🚨 If you're passionate about hematopoietic stem cells, developmental biology, and cutting-edge research, I’d love to hear from you. Feel free to share. 🩸🐠 📍 Montreal, Canada 📩 [email protected] and Ghersilab.com

🚨Excited to share that our manuscript "Transcriptional activation of regenerative hematopoiesis via microenvironmental sensing" W/ Shahin Rafii and the Twitter/X'less CompWiz Sean Houghton is out Nature Immunology 👇🏽👇🏽👇🏽 🧵 nature.com/articles/s4159…

🔥New Fraticelli lab publication🔥 “Pre-existing stem cell heterogeneity dictates clonal responses to the acquisition of leukemia driver mutations” Two new figures compared to the pre-print, with more in vivo and sequential mutagenesis data. sciencedirect.com/science/articl…

How blood ages - A curious case of mice and men. Our latest study nature published today. Biological processes such as DNA mutagenesis often scale to animal time. Blood stem cells have special evolutionary protection against this. 👉🏽nature.com/articles/s4158…

New Paper Alert! Prof. Maneesha Inamdar’s lab @BRIC_inStem investigates the role of microglia in Alzheimer's disease, shedding light on the function of Asrij/OCIAD1 in neuroinflammation. Read more here: biorxiv.org/content/10.110… Advancing neuroscience, one discovery at a time!

Our article published in Journal of Neuroinflammation! 😁 Asrij promotes microglia-mediated neuroinflammation in Alzheimer’s disease ⁦Maneesha Inamdar⁩ ⁦T Govindaraju⁩ ⁦JNCASR Bangalore⁩ ⁦iBRIC-inStem⁩ link.springer.com/article/10.118…

Exciting progress in Alzheimer’s research! 🧠 Prof. Maneesha Inamdar’s lab at BRIC-inStem is advancing studies on Asrij/OCIAD1 to reduce neuroinflammation and improve brain health. Congratulation! Department of Biotechnology iBRIC-inStem

1. My postdoctoral work on the non-canonical role of an autophagy-related protein at the spindle pole body (SPB) is now out in PLOS Biology (doi.org/10.1371/journa…).

Excited to share my co-first author paper from Sunil Laxman's lab, now out in PNAS PNASNews on mitochondrial activity independent regulation of mito-morphology via ROS. Great working with Gaurav, Aayushee & Swagata A #Mitochondria #Metabolism #Redox pnas.org/doi/10.1073/pn…

🚨 New review out! 🚨 With my amazing PhD student lydia we dive into how the chick embryo has helped shape our understanding of developmental haematopoiesis and the technologies to tackle fundamental questions🩸🧬 Read it here 👇 🔗 bit.ly/4jLMn3O

How does metabolism act through generic chromatin modifiers promote specific cellular states? Simultaneous modification of transcription factors and chromatin, enhancing epigenetic signal to noise ratios. embopress.org/doi/full/10.10…

Excited to share our latest publication in eLife - the journal: Rudhira-mediated microtubule stability controls TGFβ signaling during mouse vascular development doi.org/10.7554/eLife.… Huge thanks to all the amazing co-authors Maneesha Inamdar Preeti Jindal and Ronak 🙂

It brings us great joy to share that our PhD student, Mr. Yash Acharya, has been selected for the prestigious ASM Future Leaders Mentorship Fellowship (FLMP) by ASM Congratulations Yash acharya New Chemistry Unit JNCASR Bangalore #ASM #FLMP #AMR

Delighted to share our recent study now out The EMBO Journal; embopress.org/doi/full/10.10…. We characterized the hematopoietic niche in adult spleen, a lesser known host for hematopoietic stem cells.

Happy to share our work led by Kishalay Ghosh (কিশলয় ঘোষ) & Rohit where we show how localized & systemic genetic modulation of cellular ageing can impact organ homeostasis. Accepted version out now! The Company of Biologists journals.biologists.com/bio/article/do… Biopatrika Voices of Indian Academia

Online now: Eomes directs the formation of spatially and functionally diverse extraembryonic hematovascular tissues dlvr.it/TLXNzc

Officially Dr. Prathamesh Dongre! 🎓✨ Thrilled to share that I have completed my PhD in Cellular and Molecular Biology from JNCASR Bangalore. Huge thanks to my family, friends, and lab members for unwavering support! 🧪 🔬 Onto the next one! ❤️

Now out in the July 10th issue of Cell LoxCode in vivo barcoding reveals epiblast clonal fate bias to fetal organs: Cell cell.com/cell/fulltext/…