How do dietary glucose and fat signal to the brain to alter feeding behavior? Revisit this exciting paper from AmberAlhadeff's Lab to find out! #gutbrainaxis #diet #macros #CellMet1YearAgo #OpenAccess Monell Center

First presentations by Alhadeff lab trainees at #SSIB2022 in Porto by Aaron and Nathaniel Nyema!

When Nathaniel, a bioengineering postbac, joined the lab 2 years ago, I had no idea he would have such an ENORMOUS impact on our research program. Last night we celebrated and mourned his leaving to start a PhD Caltech. I’m so proud- watch out for great things from this one!!!

Excited to present new work at #SfN22! Tuesday afternoon poster J4! Also check out cool stuff from Ryan Post (738.02 poster FF15) and Aaron + vargas-pi (139.21 poster X13)

Flavor-nutrient learning unveiled: AgRP neurons, key drivers of feeding behavior, play a surprising role. 🧠🍽️ #neuroscience 👩‍🔬👨‍🔬Monell Center Penn 🔗sciencedirect.com/science/articl…

A new Brains in Briefs article is out now! In this edition, Aaron summarizes how NGG student Rae Herman uncovered a novel role for GLP-1R-based drugs to curb nicotine use and even prevent nicotine withdrawal-induced weight gain! #PennNGG upennglia.com/briefs/weight-…

Today in nature-- Monell Center researchers, led by AmberAlhadeff, share new findings that point towards a possible way to reduce adverse side effects of popular next-generation obesity medications like GLP1-based drugs, known as semaglutide and marketed as Ozempic® and Wegovy®

Drugs like Ozempic are great for weight loss, but they make some people feel sick. We discovered that the brain circuits mediating the appetite suppression are distinct from those that mediate nausea – a finding that may be leveraged to develop more selective GLP1-based drugs.

If you happen to be SSIB in Chicago, Misgana will be presenting this work today at 4:15 pm, where she combined chemogenetics with taste reactivity assays to measure aversion elicited by hindbrain GLP1R circuits.

One major side effect of Ozempic (and related drugs) is nausea, to the point where it is not clear whether nausea itself contributes to the weight loss. AmberAlhadeff's group used an elegant approach to identify largely dissociable circuits for nausea and weight loss.

Misgana Ghidewon presenting on using taste reactivity to disentangle aversive and anorexic circuits in the brain. AmberAlhadeff #SSIB2024

🚨 Exciting New Research Alert! 🚨 Our latest study, published in #NatureMetabolism, reveals how memory circuits in the brain drive intake of fats and sugars and impact body weight. 🍫🍟 Let’s break it down! 🧵