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Verfahren der Genom-Editierung optimiert: Heidelberger Wissenschaftlern gelingt es, die Effizienz von CRISPR/Cas9 sowie verwandten Methoden zu steigern und bislang unerreichbare DNA-Sequenzen zu modifizieren uni-heidelberg.de/de/newsroom/ve…

Here it is: our #inception paper Development „De novo PAM generation to reach initially inaccessible target sites for base editing“ by Kaisa Pakari & Thomas Thumberger We use 2 guides & 2 editors to edit distant nucleotides with NGG base-editors journals.biologists.com/dev/article-ab… #medaka #DNA

Just published Development, Kaisa (Kaisa Pakari) presents our "inception" approach to target previously inaccessible nucleotides with base-editing at the 1st Heidelberg #CRISPR mini symposium Marsilius Kolleg today - link to paper: journals.biologists.com/dev/article/15…

ahhh, bench air! Dear #miniprep, how I missed you! You routine chance for self-optimization. You simple process that grants room to think while doing, that makes automated movements happen thanks to imprinted memory in my Medulla spinalis. Even after years of abstinence. Thank U!

I guess this meeting is focusing on zebrafish fin mutants 😉

CRISPR-Fortschritte - Schnitt für Schnitt zu neuen Möglichkeiten: unser Review über sukzessive, kleine Fortschritte, die gezieltes Genomeditieren mittels CRISPR & BaseEditoren effizienter gemacht haben link.springer.com/article/10.100… ✂️ mit Kaisa Pakari & WittbrodtLab im BIOspektrum

Open PhD position in Heidelberg. Please RT! Do you want to identify the molecular mechanisms regulating genomic and chromosomal mosaicism in the developing brain? We seek a motivated doctoral researcher @COSHeidelberg Uni Heidelberg. Apply by 15 April here euraxess.ec.europa.eu/jobs/87408

Jochen Wittbrodt (WittbrodtLab) "genetics of individuality" population genetics based on our inner fish. How SNPs influence traits like the 🫀 heart beat in a Gene-by-Environment dependency (GxE) #medaka #GWAS

#GfE2024 last talk of the Stem cell session. Jochen talking about our SNP validation screen on heart-beat Gene-by-Environment alleles - CRISPR/BaseEditing SNP-fipping validated by CRISPR & ACEofBASEs editing aceofbases.cos.uni-heidelberg.de

Great talk by Christof about one of the hallmarks of #DevBio. Brings back memories of the good time I spent on the organizer during my PhD dissecting its downstream left-right organizing activity. #xenopus #cilia #LROrganizer

Announcing the fantastic keynote speakers for the 11th AQMHD Conference: Leonard Zon, Jochen Wittbrodt, and Duygu Ozpolat. Registration and more information can be found here: aqmhd.xiphophorus.txst.edu.

Are you a #DevBio researcher in Germany? Have you joined GfE as a member yet?👇

Dolf Weijers (@dolfweijers) opens the third day of #GfE2024, emphasizing two important things: 1) #DevBio is not dead but thriving in various directions obvious from the GfE/DSDB joint meeting. 2) the importance of #DevBio societies - join your local clubs!

If you desperately need to explain the problem of in vitro recombination in #PCR fooling many to believe #CRISPR/#HDR events went smooth, use the remainder space on your poster 😂 read up here for fish elifesciences.org/articles/39468 & here for the mouse academic.oup.com/nar/article/51… #GfE2024

very nice talk from Adelmann on #platynereis. She makes use of #scTranscriptomics over time during the course of regeneration and finds stem cell hotspots in different clusters 💪 #GfE2024

and furthered by comparison with other regenerating and non-regenerating fish like the surface and cave phenotypes of #astyanax. impressive talk at #GfE2024!

That's it: #GfE2024 is over. Thanks everyone for the science, amazing talks, chairing, buzzing poster sessions, short & long discussions, organizers in the back & front - simply thanks for all your contributions! See you all latest at #GfE2026 for updates & new routes of #DevBio

New high-throughput optomotor response (OMR) assay for medaka fish larvae reveals strain-specific visual function differences & training effects. Our open-source setup enables studies on visual acuity, color sensitivity & more #NeuroBiology #FishResearch 🐠journals.plos.org/plosone/articl…

Register quickly and swim by! #medaka #meeting