Inspiring innate immunology & systems biology research at this years Keystone Symposia. Grateful to get the chance to discuss our translational immunology work on anti-bacterial innate immune cell function from the HOPE-SAM study Zvitambo

tinyurl.com/3hy9kf56

Congratulations Therapeutic Approaches to Malnutrition Enteropathy (TAME) team Zvitambo The University Of Zambia on publishing multi-arm randomized phase II trial findings on novel inteventions to boost gut healing in severely malnourished children Nature Communications
tinyurl.com/3yzrsp2e

🥈 paper in Nature Communications : #TAME trial, testing medicines in children with severe malnutrition (SAM) in Zim/Zam.

Children given 14d teduglutide had a lower score of gut damage.

Is this the kickstart for novel therapies for children with SAM?
World Health Organization (WHO)

nature.com/articles/s4146…

New today in Nature Communications: characterisation of how inflammatory and cytomegalovirus-driven pathways in the circulation of mums & their babies influence mortality & immune cell phenotype in HIV-exposed infants. Great work from Ceri Evans & Zvitambo
nature.com/articles/s4146…

Two new papers from Zvitambo:

First, from the #SHINE study Ceri Evans and team shows that maternal CMV and inflammation levels predict mortality in their children in Zimbabwe.

This highlights children born to mothers with HIV as more in need.

nature.com/articles/s4146…

Severe, complicated #malnutrition has lasting negative impacts on hospitalized children in the form of intestinal and epithelial #inflammation that persists for months after recovery, shows research involving children in Zambia and Zimbabwe. Zvitambo scim.ag/6aX

Shrey Mathur and colleagues estimate the potential impact of alternative cotrimoxazole strategies on mortality in children born to mothers with HIV in Côte d’Ivoire, Mozambique, Uganda, and Zimbabwe.
Blizard Institute
Barts and The London, Queen Mary
Zvitambo
doi.org/10.1371/journa…

🔬 Zvitambo's research on children with severe malnutrition from Zim/Zam makes the cover of Science Translational Medicine!

Children 48weeks after discharge from hospital with SAM have ongoing inflammation. 🧵to follow!
🇿🇼🇿🇲
science.org/doi/10.1126/sc…

Blizard Institute Queen Mary University of London Queen Mary University of LondonBartsTheLon Claire D. Bourke

ARDENT CREATIVE launching yet another big idea!!

Absolutely enjoyed working with Professor Prendergast and the Zvitambo team Zvitambo .

Watch the space for their upcoming short film !!

Some of the team in the district of Shurugwi this week, filming a special project for Zvitambo - coming soon 🚀

🦠🔬Our paper which maps the composition and function of the gut #microbiome in children throughout 1-18 months of life in rural Zimbabwe, is out today in Nature Communications! A quick 🧵on what we found 👇

nature.com/articles/s4146…
Manges Lab Barts and The London, Queen Mary Blizard Institute Zvitambo

A sight to make my week. New immunology lab taking shape Zvitambo for Gates Foundation funded SARSCoV2 blood and mucosal immunity project (and beyond!). Lots of hard work from many to get equipment there and set up. Now for the science! Sheffield Uni - Clinical Medicine 🦠 💉 🫀💙🔬🩺

New in Science Advances today: we demonstrate the distinct ways that innate immune cells from severely undernourished children respond to bacteria compared to their adequately-nourished peers science.org/doi/full/10.11…

Applications for our 2024 UK PhD fellowships are open! jobs.lshtm.ac.uk/vacancy.aspx?r… This is a Wellcome-funded programme providing interdisciplinary PhD training in global health to outstanding UK health professionals, supported by 11 partner institutions in the UK and Africa.