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We are researchers and we are mentors, and it matters which we put first. Join us in pledging to be a #MentorFirst and encourage others to do the same. Together, we can improve mentoring in academia to benefit the next generation of researchers! mentorfirst.org

Calling all teachers - teaching material on the 2023 #NobelPrize in Physiology or Medicine is ready to use! The free lesson includes a slideshow, a short video and student worksheet. See the lesson “Discoveries that laid the foundation for mRNA vaccines”: bit.ly/3PDwhvP

Super excited to present #Blush and with it expand the applicability of cryo-EM. We reconstruct one of the smallest complexes ever with cryo-EM. A 40 kDa protein-RNA complex. biorxiv.org/content/10.110… But how do we make sure we’re not overfitting? 🧵1/4

Kinesin activates dynein via their shared adaptor HOOK3. Fun collaboration with the lab of Anne Straube (annestraube.bsky.social) . Structure of the FHF complex and the mechanism of activation by my amazing postdoc Ferdos Abid Ali Ferdos Abid Ali biorxiv.org/cgi/content/sh…

Our team at #CZImagingInstitute is excited to share the #CryoET Data Portal beta release. With over 13,000 tomograms, it’s the start of what we hope will be a large, open-access portal of high-quality, standardized & annotated cryo-ET data. bit.ly/3T9sZ6D

Excited to share my postdoc work on SARS-CoV-2 variants with John Briggs. Fun collaboration with Tom Peacock Jonathan Brown Imperial College London; Tristan Croll and Abhay Kotecha. The work started 3 years ago at the beginning of the Alpha variant @MRC_LMB and finished at Max Planck Institute of Biochemistry (MPIB)

Virion morphology and on-virus spike protein structures of diverse SARS-CoV-2 variants. Preprint from Zunlong Ke in collaboration with Tom Peacock wendybarclay Abhay Kotecha Tristan Croll and others. biorxiv.org/content/10.110…

Fantastic and productive time there last summer! Melanie is a great teacher! Couldn't recommend more!

"Integrating cellular electron microscopy with multimodal data to explore biology across space and time"🔬👩‍💻🌌⏳ cell.com/cell/fulltext/… Our new review is online Cell. Big thanks to our amazing co-authors @computingCaitie Sven Klumpe Rommie Amaro Wanda Kukulski @EM_STP

A coopted retrotransposon gene forms virus-like capsids associated with paraneoplastic neurological syndrome. Thanks Junjie Xu Jason Shepherd Cedric🧬➰🧬Feschotte et al for a fascinating collaboration. Structures by Simon Erlendsson. @MRC_LMB Max Planck Institute of Biochemistry (MPIB) sciencedirect.com/science/articl…

Truly excited for Zunlong Ke to set off to UT Austin to start his own research group!! It’s this kind of bittersweet moments when our team bids farewell to a great colleague yet the world welcomes a promising PI. Aaand of course we named a plant after Zunlong in our office 😅

Over 4 years in the making, I am excited to share our pre-print on the “In-cell structure and snapshots of copia retrotransposons in intact tissue by cryo-electron tomography”. We used cryo-ET to resolve the copia capsid structure to subnanometer resolution inside cells. A 🧵

Big congratulations to our Prof. Jason McLellan Jason McLellan Molecular Biosciences NaturalSciences @ UT UTexasILS for receiving the 2024 "Building the Foundation Award" from Research America ResearchAmerica for his structure-based vaccine design 🦠💉. x.com/ResearchAmeric…

Great work by super star grad students and postdoc/new PI Grace Hibshman, Matt Hooper, and Jack Bravo Molecular Biosciences NaturalSciences @ UT. Colab with Johnson lab and finally the other CRISPR guy Ilya Finkelstein! Lots to see. My favorite: the SpRYmer. link.springer.com/10.1038/s41467…

Our #cryoET study of #RSV is out in Nature Communications!! rdcu.be/dNKAk Using #subtomogram averaging we show the matrix protein packs as a helical-like lattice. The Fusion gp arranges as F-trimer pairs & correlate w/the M lattice. Great work Bryan Sibert & coauthors!❄️🔬🦠

A fun journey of full-length EGFR with Dan Leahy and Edward Marcotte Molecular Biosciences UT Austin. See the full report below: Structure and organization of full-length Epidermal Growth Factor Receptor in extracellular vesicles by cryo-electron tomography biorxiv.org/content/10.110…

Cryo-ET unravels the mystery of Ad5-nCoV vaccines dlvr.it/TKbbLR