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Incredibly proud of a new study, led by brilliant Naomi Goldman, demonstrating for the first time that the intrinsically disordered domain of TCF-1 is critical for T cells. We are grateful to exceptional collaboration in Laboratory of Genomic Immunology and beyond tinyurl.com/yj462k8s

Congrats Tyler~

Congrats Jenn! Well deserved work~

Congrats Gilbert!

BREAKING NEWS The 2023 #NobelPrize in Physiology or Medicine has been awarded to Katalin Karikó and Drew Weissman for their discoveries concerning nucleoside base modifications that enabled the development of effective mRNA vaccines against COVID-19.

Excited to share our paper on the first small molecule inhibitors of PTPN2/PTPN1 for cancer immunotherapy out today in nature nature.com/articles/s4158… This has been a collaboration with Calico and AbbVie. Very proud of the amazing team that made this happen! Explainer below👇

Congrats Rob! Really glad to see the amazing effect of this drug, it can be a milestone for tumor immunology~

More from less - target over 13,000 genomic sites with 24 guides! Excited to share our new paper on bioRxiv on multi-locus CRISPRi. Thanks to all co-authors! #BroadInstitute #GRO #CRISPR biorxiv.org/cgi/content/sh…

Congratulations Fadi! This is amazing work~

Proud to share our latest work, Co-led by Chadi A. El Farran & Charles Couturier, MD, PhD-under mentorship of Brad Bernstein where we develop a new framework to understand immunomodulatory myeloid cells in glioma & lay a foundation to develop effective immunotherapies biorxiv.org/content/10.110…

Congrats Tyler, Chadi and Charles~Such a encyclopedia for myeloid cells in GBM~

Excited to share Lamian - a statistical framework for differential pseudotemporal trajectory analysis across biological conditions using single-cell RNA-seq data from multiple samples. Wenpin Hou zhicheng ji Zeyu Chen E. John Wherry Stephanie Hicks, PhD rdcu.be/dqMlh

Guess what?! The Jason Buenrostro and Fadi Najm labs got a Broad SPARC award! Incredibly grateful for this opportunity. Thanks to the Broad SPARC committee and benefactors who empower us to push the limits and dream big Broad Institute Gene Regulation Observatory

This week we held our Third Annual GRO Retreat Broad Institute and it was a blast! Thank you to our keynote speaker Benjamin Ebert, our visiting speaker Sara Mostafavi & all of our contributing discussion leaders, breakout participants, poster presenters. An incredible group!

Wonderful day of science. Thanks to all!

Finally HACE is out~let's moving towards mammalian endogenous directed evolution at single base resolution~

Congrats Jesse! This is amazing work~

Congrats KL! Super amazing work~

Congratulations Divij! Really glad to see this milestone story is finally online!

Thank you Dawn and congrats everyone! HACE is online now Science Magazine ~in situ directed evolution method.