Congratulations to Jason Rogers, Rohit Gupta, Cade Johnson, MD, MBA, MPH, Geraldo Medrano M.S. and so many lab members past and present for getting this across the finish line with tremendous support from Peggy Goodell. Thx to Blood Advances for publishing our work! ashpublications.org/bloodadvances/…

Paul Nurse, who won a Nobel for his work on the cell cycle, calls for more daring theory in biology and criticizes current trends in large scale data generation. We probably need to reimagine the Discussion section of papers! nature.com/articles/d4158…

[Please RT] We are hiring a research assistant in the Chang lab Stanford Medicine! This person will work with me on exciting research aiming to understand how oncogenes on extrachromosomal DNA drive cancer. Apply here: m.rfer.us/STANFORDS85G8B

Our October 2021 issue marks 20 years of Nature Reviews Immunology - see our special anniversary collection: go.nature.com/3nqaVp9

People have long thought that astrocytes release something that kills neurons, which could partly explain why neurons die in injury/neurodegenerative disease. In a paper that just came out, we think we found one of these long-sought toxic factors! (1/8) go.nature.com/3afi6si

A terrible call ruins an epic series.

Our paper is out in nature! Extrachromosomal DNA molecules huddle together in cancer cells to activate oncogene expression (which we call ecDNA hubs). A great collaboration with Katie Yost, Howard Chang, Frank Xie lab, Zhe Liu, and others. (1/10) nature.com/articles/s4158…

Today we report in Cell an engineered virus-like particle (eVLP) platform that mediates efficient in vivo delivery of therapeutic proteins, including base editors and Cas9 nuclease, resulting in therapeutic editing in multiple mouse organs. 1/14 drive.google.com/file/d/1GdJLA4…

🥳new pre-print!🥂 Clonal mosaicism is THE frontier in human genetics. But we know next to nothing about phenotypes of mutated cells in humans. Single-cell multi-omics allowed us to link genotype-phenotype directly in primary human clonal hematopoiesis🎉 biorxiv.org/content/10.110…

Happy to see this out and proud of Yung-Hsin Huang, Ph.D. for a herculean effort. #DNMT3A mutations are common in heme malignancies, clonal hematopoiesis, and Tatton Brown Rahman Syndrome (TBRS) Community. Many variants of uncertain significance we wanted to understand.

Spatial-CUT&Tag! Science Magazine, unfolding a new chapter of #spatialomics 🤗 . From my phenomenal postdoc Yanxiang Deng of @YaleSEAS @YaleBME, Yale Pathology Yale School of Medicine Yale Cancer Center Thanks to awesome collaborators GonçaloCasteloBranco Marek Bartosovic Petra Kukanja science.org/doi/10.1126/sc…

Incredibly excited to share our paper ‘Somatic mutation rates scale with lifespan across mammals’ now published @nature. nature.com/articles/s4158… An illustrated & updated tweetorial… [1/24]

📢 ONLINE Nature Genetics 📰 The disordered N-terminal domain of DNMT3A recognizes H2AK119ub and is required for postnatal development 🧑🏿‍🤝‍🧑🏼 Margaret A. Goodell and team ⬇️ go.nature.com/3LX6cVe

Excited to share our latest study on #DNMT3A identifying a new chromatin reader domain in the N-terminus that is essential for post-natal life. rdcu.be/cNbF5

Our crazy journey on this continues - New Hanna lab Cell paper is out: "Post-Gastrulation Synthetic Embryos Generated Ex Utero Solely from Mouse Naïve ESCs" by the amazing @TaraziShadi Alejandro Aguilera Castrejon @carinejoubran Noa Novershtern & Itay Maza cell.com/cell/fulltext/…

Thrilled to share our paper in Nature Genetics! Cancer cells often amplify oncogenes outside chromosomes. We can now isolate and profile these large circular extrachromosomal DNA (ecDNA) molecules using a method called CRISPR-CATCH. 1/10 nature.com/articles/s4158…

A great loss for the epigenetic field. R.I.P Dr. Allis

Happy to share our paper describing SPACE-seq - a new approach to spatial multiomics and lineage tracing - out today in PNASNews! 🧵(1/5) pnas.org/doi/10.1073/pn…