In 24 hours: Nate Pope (University of Oregon) on "Untangling ancestral recombination graphs to infer complex demographic scenarios" youtube.com/watch?v=cjSYaN…

For many traits there is a correlation between the number of duplications or loss-of-function (LoF) mutations someone carries, and their phenotype. Curiously, for most traits, these effects are aligned in the SAME direction. Why?

Today is a very big day for our research group, with two of my students, @arevsumer and Leonardo N. M. Iasi publishing papers on the same day! science.org/doi/10.1126/sc… nature.com/articles/s4158… #Neanderthals #Geneflow

Enthralled to see our work published in Science. This wouldn’t have been possible without the wonderful contributions of the team comprising @moorjani_priya Leonardo N. M. Iasi Benjamin Peter @SkovLaurits Mateja Hajdinjak Alba science.org/doi/10.1126/sc…

This work about the severe African bottleneck hypothesis is now published on Genetics at: doi.org/10.1093/geneti…. More details can be found at our previous thread below:

Happy New Year! Our Twigstats paper is now out! nature.com/articles/s4158…

Our work, which shows statistical issues with the previous claim of a severe ancient bottleneck in the ancestry of African populations, has been selected as a Featured article in Genetics Society of America doi.org/10.1093/geneti… Great work by Yun Deng 邓赟, co-advised by Rasmus Nielsen and me 1/2

Modern GWAS can identify 1000s of hits but it can be hard to turn this into biological insight. What key cellular functions link genetic variation to disease? I'm excited to present our new work combining associations + Perturb-seq to build interpretable causal graphs! A🧵

I'm incredibly excited to announce that I'll be joining the Institute for Disease Modeling at the Gates Foundation in Seattle! I've long admired the Gates Foundation's impactful work in global health, and I'm grateful for the opportunity to be a part of the terrific IDM team.

will forever point out that PhyloP, a traditional probabilistic model, has a fraction of the compute cost and does as well or better than many of these foundation models

Excited to share our latest preprint on the impact of background selection on complex trait evolution. It’s amazing to finally see one of the major projects from my PhD journey come to life. Huge thanks to Jeremy J. Berg and John Novembre for their guidance and support.

Postdoc position in my group in Tokyo! Please get in touch if you are interested. And happy to discuss projects - ranging from developing new methods to analysis of new genomes that we are now sequencing in the lab. riken.jp/en/careers/res… Lab page: speidellab.github.io

I am thrilled to announce that I will be starting my own lab at NYU Biology Jan 2026! Soon enough I will be recruiting postdocs and students! Please reach out if you are interested with a CV and description of your research or if you know of people who could be interested!🧬🦊

Staff scientist position (computational): I am looking for a computational scientist to join my genomics lab at Stanford. They should have an outstanding skillset in ML/statistical methods for genomic applications, postdoc experience and a strong publication record. #sciencejobs

Science Magazine There are at least three papers recently published that strongly contest the claim made in this paper, each drawing on a different evidence academic.oup.com/genetics/artic… academic.oup.com/mbe/article/42… biorxiv.org/content/10.110…

Our method for posterior sampling of Ancestral Recombination Graph, SINGER, is now published at Nature Genetics: nature.com/articles/s4158…. Come and check it out! Here is our previous Twitter thread with detailed explanations of the work.

We are excited to share GPN-Star, a cost-effective, biologically grounded genomic language modeling framework that achieves state-of-the-art performance across a wide range of variant effect prediction tasks relevant to human genetics. biorxiv.org/content/10.110… (1/n)