Women and aging. agsjournals.onlinelibrary.wiley.com/doi/10.1111/jg…

Just published in NEJM 🔥 Degenerative Rotator-Cuff Disorders 👇👇👇 nejm.org/doi/full/10.10…

An online driving decision aid for older drivers reduces ambivalence and regret about driving decisions: Randomized trial. #geriatrics agsjournals.onlinelibrary.wiley.com/doi/10.1111/jg…

Deprescribing considerations for central nervous system-active polypharmacy in patients with dementia. #geriatrics agsjournals.onlinelibrary.wiley.com/doi/10.1111/jg…

It all started with one cell

For ACP Journal Club, research staff from McMaster University and clinical editors summarize the best new evidence for internal medicine from over 120 clinical journals. Up now, COVID-19, ischemic stroke, and more. bit.ly/4f3dDbp

Chemotherapy

2. A vaccine given by rubbing it into skin S. epidermidis (universal skin bacteria) were engineered to express part of the tetanus toxin, and swabbed onto skin This protected these mice from tetanus (left), but not unvaccinated control mice (right) nature.com/articles/s4158…

6. We need to personalise blood test ranges An individual's ranges are much more narrow than the 'normal' reference range And when the numbers change - even when they're within the reference range - it alters disease risk and survival outcomes nature.com/articles/s4158…

The biochemistry of love "Without loving relationships, humans fail to flourish, even if all of their other basic needs are met"

Atrial fibrillation (AF) is associated with increased rates of stroke, heart failure, and mortality. This narrative review examines the epidemiology, pathophysiology, diagnosis, and treatment of AF. ja.ma/3ZDdZ2D

2024's top 10 advances in medicine (🧵) 1. The numerous benefits of GLP1R agonists As well as causing weight loss, GLP1s can prevent complications of obesity (diabetes, liver fibrosis, kidney disease, osteoarthritis), treat heart failure, and even slow down Parkinson's:

5. A treatment to prevent weight and muscle loss (cachexia) in cancer Cachexia is driven by the stress-responsive cytokine, GDF15 If GDF15 is blocked with a monoclonal antibody, patients gain weight, gain muscle, have more appetite, and can do more physical activity:

9. Restoring communication in motor neuron disease In a patient with motor neuron disease (ALS) and loss of speech as a result, a brain implant read the neural activity of his attempted speech and produced it via a computer - in his own voice:

Taxi drivers and ambulance drivers, whose jobs require frequent spatial and navigational processing, have the lowest levels of death attributed to Alzheimer’s disease compared with other occupations, finds new study #ChristmasBMJ Anupam Jena bmj.com/content/387/bm…

Big news: Rare back-to-back studies nature provide evidence a bile acid called LCA mediates the health & age slowing benefits of low-calorie diets, and may be the elusive endogenous SIRT1 activator that resveratrol mimics. Details below 🧵 tinyurl.com/55dxb859

Use of glucose-lowering medications in the management of type 2 diabetes. American Diabetes Association - DiabetesPro Standards of Care in Diabetes–2025 diabetesjournals.org/care/article/4…

How do we make sense of two “negative” trials in NEJM and a “positive” meta-analysis of the two trials in NEJM Evidence? Emil Hodzic-Santor and Michael Fralick share some insights in this editorial: eviden.cc/3OYutgJ

How Anger changes your brain

New Psychological Research Challenges Popular Aging Myths. news.google.com/rss/articles/C…