After a lot of trial and error, I finally managed to reconstitute a major step in #membranetrafficking: The real time conversion of PI(4)P (Cyan) into PI(4,5)P2 (Magenta). And it looks absolutely stunning #FlourescenceFriday

Some rare personal news… My first calling, as many of you know, was writing. I’ve always found (unreasonable levels of) joy in working with words. Now I’ve somehow written a book: Projections. Random House Group penguinrandomhouse.com/books/600209/p… 1/12

1-4. It’s out ! Apoptotic epithelial cells induce ERK waves locally promoting cell survival.

Video of #SARSCoV2 infecting brain cells (gray blobs) with cell fusion, hijacking, and explosive release of copies for more invasions nytimes.com/2021/08/22/sci… NYT Science Andrew Jacobs by Sophie Aicher and Planas Delphine Institut Pasteur, since 1887 justsaysinrats Nikon Small World

I never get tired of watching #rotavirus #calciumsignaling in action. 🌊🌊🌊 Cool things to look for: 1) Ca2+ waves are cooperative?🤯 Watch the 2 cells in the upper right at ~70 min. 2) A cell 'waves' goodbye! 👋💥Watch for the Super-duper cell death Ca2+ wave at ~100 min.

Excited to see our paper published in Nature Communications today! Our newly developed "Nano-crown" electrodes record parallel and accurate intracellular electrical signals from heart muscle cells, for pre-clinical evaluation of drug candidates. nature.com/articles/s4146…

News from Nature Cell Biology about curved adhesions. Years of hard work. Congratulations to Wei Zhang and co-authors!

Check out Dr. Wei Zhang's work characterizing a new type of adhesion. Such curved adhesions are integrin beta5-based, sensitive to membrane curvatures, composed of architectures different from focal adhesions, and bearing low but constant forces!

#FluorescenceFriday #cellbiology #bioart The interior of the cell is a busy place, as seen by grazing incidence structured illumination microscopy at 30 frames per minute: Lysosomes (green) can become corralled by the endoplasmic reticulum (ER, magenta), but can also remodel the

Our latest work on the spatial regulation of ER-PM contact by membrane curvatures in cardiomyocytes is in bioRxiv now! We hope that we've provided an explanation of the long-observed enrichment of ER-PM contact at the transverse tubules.

Our recent published paper from my pre-PhD training at Min WU! Shoutout to our reviewers for their constructive suggestions that strengthened our story and helped us uncovered details that we almost overlooked! #actin cell.com/cell-reports/f…

Thrilled to share that I will join Johns Hopkins University Johns Hopkins BME as an Assistant Professor in 2025! The Yang Lab will develop novel bioelectronics and biomaterials for brain-machine interfaces, regenerative medicine, and the study of human neural development and diseases.

Excited to share our work published in NCB! We uncovered how plasma membrane curvatures spatially modulate ER-plasma membrane contacts, shedding light on the enrichment of these contacts at T-tubules in cardiomyocytes.Thank you to all our collaborators and everyone in the CuiLab!

An isolated microglia (red) exerts mechanical forces on astrocytic processes (green) within the injured brain of a young zebrafish. Like a microscopic bow bent by a tiny archer aiming to heal the wound. #FluorescenceFriday

Sometimes Nature is stranger than fiction! Enjoy a blast from the past.

Mitotic ER-mitochondria contact enhances mitochondrial Ca2+ influx to promote cell division dlvr.it/TDqqnG

Inaugural pop-up Focus Session at APS on “Do details matter in living matter?”   Biologists/physicists working on single cell oscillations, please submit abstract by Oct 25! summit.aps.org/attend/abstrac… American Physical Society Bement Lab Yale Program in Physical and Engineering Biology #APSSummit25

Excited to share our new paper "Actin-driven nanotopography promotes stable integrin adhesion formation in developing tissue". rdcu.be/dWie7 We study the single molecule dynamics of integrin adhesion proteins in developing Drosophila embryonic muscle attachment.

I am super excited to share our article addressing a longstanding question in neurobiology: how Ca²⁺ signaling cascades initiated at dendritic spines operate at a distance. Check it out here: authors.elsevier.com/sd/article/S00… Cell

Now our job post is out in Nature Careers. We have recruited one and have a few more positions. Please RT and spread the news. ISSCR nature.com/naturecareers/…