Take your ExM to the next level! Click-ExM uses click-chemistry-based labeling to enable imaging of numerous classes of biomolecules including lipids, glycans, proteins, DNA, RNA and small molecules. nature.com/articles/s4159…

.Xing Chen and colleagues from Peking University report a bump-and-hole approach for metabolic glycan labeling in cells and living mice. Free to read: rdcu.be/cMQMl nature.com/articles/s4158…

O-GlcNAc modulates LLPS in synapses. check it out: doi.org/10.1038/s41557…

Chemoproteomic and Transcriptomic Analysis Reveals that O-GlcNAc Regulates Mouse Embryonic Stem Cell Fate through the Pluripotency Network (Chen) Xing Chen Peking University onlinelibrary.wiley.com/doi/10.1002/an…

This is an example on where S-glyco-modification really matters and by avoiding it, the use of azidosugars is expanded. Metabolic Glycan Labeling in Primary Neurons Enabled by Unnatural Sugars with No S-Glyco-Modification | ACS Chemical Biology pubs.acs.org/doi/10.1021/ac…

Cellular-scale proximity labeling for recording cell spatial organization in mouse tissues science.org/doi/full/10.11…

Proximitomics by Reactive Species | ACS Central Science pubs.acs.org/doi/10.1021/ac… Our recent Outlook is out now. We reviewed recent advances in proximity labeling at multiple scales with reactive species. Check it!