From MBoC Improved tools for live imaging of F-actin structures in yeast Enhanced Lifeact probe drastically increases detection of F-actin in vivo at low expression levels, without altering cellular actin dynamics or organization Bruce Goode doi.org/10.1091/mbc.E2…

What drives cytoplasmic mRNA organization? We created unbiased, genome-wide maps of mesoscale RNA-RNA spatial proximity to find out - Biggest surprise was impact of encoded protein function. Fantastic work w/ Lindsay Becker Sofi Quinodoz David A Knowles (@davidaknowles.bsky.social) biorxiv.org/content/10.110…

A new Science study finds that different dendritic segments of a single neuron follow distinct rules. The results challenge the idea that neurons follow a single learning strategy and offer a new perspective on how the brain learns and adapts behavior 📄:

How do altered levels of lamins and other nuclear envelope proteins contribute to cancer metastasis, and how does this relate to #mechanobiology? Learn more in our recent review by Sarah Henretta now out in npj Journals - biological physics and mechanics (doi.org/10.1038/s44341…).

Sequence-based prediction of intermolecular interactions driven by disordered regions | Science science.org/doi/10.1126/sc…

Biomolecular condensates organize cellular contents. Most studies focus on passive phase separation, driven by salt, pH, or temperature. But what if intracellular movement also matters? science.org/doi/10.1126/sc… Here, we explore motility-induced condensation in a cellular context.

The Allen Institute announced the launch of CellScapes, a bold new research initiative aimed at revolutionizing how scientists understand and predict the behavior of human cells as they work together to build tissues and organs. 🔎 Check it out! bit.ly/4jshL6K

Excited to join this #Worm25 workshop on AI for high-throughput C. elegans research! I'll be sharing how we're using cutting-edge models to decode worm behavior at scale.

Just shared a review on mechanosensing protein linkages — their roles in force transmission and potential as therapeutic targets. 🔗 pubs.aip.org/aip/apb/articl… #Mechanobiology #ProteinEngineering #DrugDiscovery Mechanobiology Institute

Finally here! Our preprint on the MOSAIC, a multimodal adaptive optical microscope enabling non‑invasive in‑vivo imaging from molecules to organisms, is out. biorxiv.org/content/10.110… Eric Betzig Legant lab

So proud of XIANGYI DING from the Starr-Luxton lab featured in @NatureMethods! The collaborative spirit she describes captures what we're creating through our @PaulGAllenFront supported work with Daniel Starr at @UCDavis #Frontierscience nature.com/articles/s4159…

It’s on!!! #Worm25

Excited that our nucleolus mapping paper just came out today in Nature! Truly an amazing study from even more amazing due of Sofi Quinodoz & Lifei jiang w/ Denis LJ Lafontaine & Sebastian Klinge and other fantastic co-authors nature.com/articles/s4158…

Our tour de force into the nucleolar world — a stunning exploration of spatial organization and the functional choreography of ribosome biogenesis now out in Nature✨ tinyurl.com/5n7jk3uz Led by Sofi Quinodoz, Lifei jiang, brangwynnelab, with theory partners Qiwei Yu,

Chromatin heterogeneity modulates nuclear condensate dynamics and phase behavior. Congratulations Jing! Happy to have contributed in a small way to this interesting work! nature.com/articles/s4146…

How does the cell membrane adapt to its environment? Douglas Robinson and Amy Rowat are developing CRISPR-powered technologies to identify proteins that impact cell membrane mechanics, particularly how membranes adapt to physical stress. #FrontierScience alleninstitute.org/division/front…

Regulation of inflammatory responses by pH-dependent transcriptional condensates: Cell cell.com/cell/fulltext/…