🔥Telegram İfşa

Don't have a binder to your favorite E3 yet - no problem! Congratulations to lead author Yunan Zheng and colleagues at AbbVie on their work using non-canonical amino acids in E3s which can be linked via click chemistry to a target binder. pubs.acs.org/doi/10.1021/ja…

So happy and proud to see our story online!! Thank you, the midnolin team!

Check out our lab's newest pub, live in ACS ChemBio! We report interesting CRBN-independent activities of N-alkylated lenalidomide derivatives, or "capped imides." Congrats to Farah and all of the authors! 🥳💐 pubs.acs.org/doi/10.1021/ac…

Super grateful for the generous support from Esther A. & Joseph Klingenstein Fund! We are excited to make more discoveries uncovering the roles of the midnolin-proteasome pathway in neurons!

We hope everyone is as in love with this cover as we are! 🤩

Congratulations to Katherine A Donovan and colleagues at DFCI on their work uncovering numerous interactors of CRBN glues!

Improvement of a DCAF1 binder that can be applied to targeted protein degradation co-led by Serah Kimani, PhD at the SGC, University of Toronto. Congratulations! Link below: nature.com/articles/s4200…

Congratulations to Kate Stuart, Rebecca Teague, and colleagues at PhoreMost on their work towards more rational design of molecular glues! Many ways to augment the surface and binding capabilities of E3 ligases. biorxiv.org/content/10.110…

Our evolved and engineered CRBN derivative used to enrich and visualise C-term cyclic imide-containing proteins, aka "Cerebody," is now live and in stereo in Cell Chemical Biology!🫡🎉💛 Congratulations to everyone behind this cool work! Huzzah! sciencedirect.com/science/articl…

Pleased to share Dr Nur Kocaturk has been awarded a Cross-Sector Experience Award from Academy of Medical Sciences This funding will allow them to collaborate with Promega Corp to co-develop a new cellular ligand finding platform for intractable disease related proteins.

Congratulations to Selina Zhang Selina Zhang who has been awarded one of our conference scholarships to attend the Lorne Ubiquitin Conference in Australia! Read more about her and the exciting doctoral work in ALS she is doing below. #WomenInTPD

While a spoonful of sugar helps the medicine go down, glycosylated PROTACs are a nifty way to metabolically control PROTAC activity 🤩🟦🍬 Check out our newest work out now is J. Am. Chem. Soc. 🫡 Congrats to Chace and all authors! 💐🎉🐱 pubs.acs.org/doi/full/10.10…

Congratulations to the Woo lab on their new approach to gate activity using an O-GlcNac modification on the CRBN bifurcational!

If you are in the Boston area at the end of October do not miss our free, in-person networking event on Wednesday, October 29th from 5:30-7:30pm! Thank you so much to Kymera Therapeutics for hosting. Register below at this link: eventbrite.com/e/women-in-tpd…

The Aug-Sept Journal Club is ready!! Thanks to our amazing editors: Aitana de la Cuadra Basté, Nicola Murdoch, Qinghzi, and Michael. If you are interested in the latest TPD literature, have a look! buff.ly/JQPQrXK #openaccess #TPD #journalclub UoD Life Sciences

What can you degrade if you bifunctionalize the CRBN binder to an agnostic chemical library? Turns out a lot of proteins! Read this fascinating work below led by the talented Ines Forrest, Ph.D. , Ph.D and colleagues at Scripps on their approach using AgnoTACs. pubs.acs.org/doi/10.1021/ac…

From the Bristol Myers Squibb team co-led by Lynda Groocock and Deborah Mortensen comes the story of developing a BCL6 oral degrader with pM potency and excellent TGI. Fantastic work everyone! pubs.acs.org/doi/full/10.10…

Fantastic panel and discussion last night including Katherine A Donovan (DFCI) and organized by Lori Friedman (ORIC) at the AACR-NCI-EORTC Town Hall on "The Promise of Molecular Glues in Cancer Treatment: Will it stick?"

Congratulations to Dr. Nur Kocatürk on being awarded a Women in TPD & Induced Proximity conference scholarship to attend the 8th Annual Hanson Wade TPD and Induced Proximity conference in Boston! 👏👏👏

She’s our greatest star of all! ⭐️ Big big congratulations to our boss 🫡