By combining genomewide histone modifications, gene expression and disease GWAS loci in muscle samples from sedentary or endurance trained men, this study in Molecular Metabolism links exercise to reduction in risk for multiple diseases. sciencedirect.com/science/articl…

Join my team @ Maze Therapeutics where we are using human genetics insights to develop new therapies for patients: mazetx.com/careers/?gh_ji…

The conversation continues right here! We're now on Twitter. Follow us to stay in-the-know as we unveil our progress in genetic medicines and other post-worthy info. #FurtherTogether #ImpactObsessed

I am excited to share the pre-print of my postdoctoral work: Exploring the rules of chimeric antigen receptor phenotypic output using combinatorial signaling motif libraries and machine learning. biorxiv.org/content/10.110… #synbio #immunotherapy (1/7)

Almost exactly three years since we launched to translate genetic insights into medicines. Excited to tell you more about our lead program and the critical role played by human genetics. 1/n

Pleased to be part of 1/2 nature pubs linking TDP-43 mislocalization with missplicing/loss of unc13a, providing mechanism for well established ALS gene and suggesting a novel therapeutic approach. Beautiful example of road from GWAS -> fxn -> therapeutic hypothesis. 1/n

Excited about my visit to UW tomorrow! See you there!

Here is an explanatory video of our recent paper "Decoding CAR T cell phenotype using combinatorial signaling motif libraries and machine learning" in Science Magazine led by Kyle G Daniels. The video is narrated by CDI Director Wendell Lim. youtube.com/watch?v=iQT-4y…

Our paper, “Programming multicellular assembly with synthetic cell adhesion molecules” is now online ahead of print. nature.com/articles/s4158… @nature @ucsf Cell Design Institute @UCSF Fletcher Lab (and Andrew Harris), Faranak Fattahi Ophir Klein Josiah Gerdts Wesley McKeithan

november NewLimit: - first reprogramming screens - 10x'd reprogramming library manufacturing - first epigenetic mapping experiments december: - NGS read outs for the above -- our first DBT loop! - initial functional assays - you recommend someone? blog.newlimit.com/p/november-202…

we've assembled a team of amazingly talented people & continue to recruit broadly please reach out if any of our open roles are of interest: newlimit.com/careers

Check out our paper Science Magazine. We engineered synthetic T cell circuits that locally produce the cytokine IL2. Specific configurations of IL2 circuits dramatically improved T cell clearance of solid tumors without systemic toxicity. Cell Design Institute @UCSF #SynBio science.org/doi/10.1126/sc…

We're excited to announce that we've raised our Series A from DIMENSION, Founders Fund, & Kleiner Perkins blog.newlimit.com/p/newlimit-ser…

$40M from DIMENSION, Founders Fund and Kleiner Perkins + Eric Schmidt, Fred Ehrsam and Elad Gil. Small team. 17 people, growing to 25 for the next two years. Everyone executes and everyone learns to company build. Come discover the passphrase to youth! newlimit.com/careers

early autumn NewLimit: - 6X'd the # of reprogramming factors we've tested - >4X'd signal-to-noise for our core pooled screening assay - shortened feedback cycles by 40% - improved in silico reprog models >30% all covered in our latest blog

We have found early evidence that three of our hits can restore youthful function in old T cells (an important immune cell). This was a big results for us. Our first batch of screens found many hits that could make old T cells "look" younger (based on RNA seq profiling). This new

Went transcription factor hunting today NewLimit

NewLimit has raised a $130M Series B led by Kleiner Perkins alongside Nat Friedman/Daniel Gross, Khosla Ventures, HUMAN CAPITAL and returning investors DIMENSION & Founders Fund We're grateful for their boldness in joining us on our journey to extend human healthspan

we're expanding our functional genomics team NewLimit we're recruiting both research associates & scientists. this team runs the world's largest reprogramming screens, first humanized in vivo screens, and pushes the frontier of genomics tech each month. we grow deliberately, so

Great overview of the work NewLimit is doing to extend human longevity Worth subscribing to Core Memory on YouTube as well