Our paper on aromatic radical cyclases is out in Nature Catalysis: nature.com/articles/s4192… We expanded metalloredox radical biocatalysis to arene functionalization. These P450 radical cyclases are highly malleable:

We thank Nature Catalysis for featuring our radical cyclases on the cover of their July 2023 issue! Peng Liu Group

Catalytic asymmetric dearomatization is a powerful tool to convert flat aromatic compounds into 3D scaffolds. However, catalytic asymmetric dearomatization via a radical mechanism is difficult. We provide a new biocatalytic solution: nature.com/articles/s4155…

We evolved P450 radical dearomatases (P450rad) with new enzyme functions not known in nature. With engineered P450rad enzymes, a series of indoles, pyrroles and phenols underwent asymmetric radical dearomatization in a stereoselective fashion