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3D_omics is looking for a #postdoc to apply Genome Architecture Mapping to #spatialgenomics + #transcriptomics on the analysis of #microbiome composition + spatial organisation relative to the intestinal epithelium w/ Prof Ana Pombo. Sign up at our website to find out more on 30/11!

The Omicron variant is a cause for concern — but not panic. We will fight this variant with science and speed — not chaos and confusion.

I am very excited to share the Riccio Lab @ LMCB new preprint on a novel enhancer for the important neurotrophin-encoding gene Bdnf. biorxiv.org/content/10.110… 1/7

Postdoc position in our lab Karolinska Institutet available on epigenomics, single cell, spatial or wherever your curiosity and imagination drives you! Deadline Jan 16! ki.varbi.com/what:job/jobID…

My holiday break project was to re-imagine these beautiful snowflake microglia posted by Celia Luchena. The image was created and rendered in 3D using Blender 🔶. They even glow!

As a scientific group and one with Russian nationals, we strongly condemn the actions of the Russian government and appeal to put an end to this war and restore peace at the earliest. #StopWarInUkraine

Happy to share that our new study describing how the inherited non-coding single-nucleotide polymorphism rs55705857 drives IDH-mutant glioma is (finally) published. This was a close collaboration Mayo Clinic Comprehensive Cancer Center science.org/doi/abs/10.112…

Published in Science Advances ! Study of schizophrenia by combination of single cell and spatial transcriptomics: Upper cortical layer–driven network impairment in schizophrenia. science.org/doi/10.1126/sc…

Excited to share our latest work @nature on 3D genome organization alteration in AML. Great collaboration with Hong Zheng, Leonidas Platanias, MD Aaron Viny Ross Levine Yarui Diao and many others. Led by two outstanding students Jie and Fan. nature.com/articles/s4158…

Come and join us – awesome community, great resources, and a cool city! Besides, in this crazy world is there a better place to be than Canada? 🇨🇦

There is now an open postdoc position in my group with focus on single-cell and spatial analysis of the epigenome during brain development. If you are interested in working with cutting-edge multimodal technologies apply here 👇Please RT! jobrxiv.org/job/stockholm-…

Very happy to share our newest paper describing how loss of epigenetic regulation disrupts lineage integrity, induces aberrant alveogenesis, and promotes breast cancer aacrjournals.org/cancerdiscover…

My last postdoc paper is out! sciencedirect.com/science/articl… … we’ve added some fun in vivo data (in utero electroporation to follow neuronal migration, which is abrogated by enhancer knockdown) since the pre-print.

I am really excited 🥳 that this work is now out in Nature Biotechnology What used to be sci-fi is now possible! Profile 3 epigenetic modalities with single-cell resolution using sc-nano-CUT&Tag.

Some thoughts on core facilities. 1. These are enormous all-boat lifters if supported well. 2. They should be run by experts who are commensurately valued and supported. This is a career path. Include names on papers if they’ve contributed insight, even if fee-for-service. /1

Thrilled to see our new paper out in Nature Biotechnology . Spatial-CITE-seq: spatially resolved co-indexing of transcriptome and epitopes for multi-omics sequencing. Big shoutout to Yang Liu, my former postdoc @YaleBME and now assistant professor of pathology and neurology Yale School of Medicine !

Another great collaboration with Rong Fan Yale University! Taking advantage of the great flexibility of Rong's DBit-seq to simultaneous spatially profile RNA & ATAC and RNA & histone mods genome wide, in the same brain tissue section! Check it out nature nature.com/articles/s4158…

Our paper uncovering the role of SRRM2 splicing factor in stem cell pluripotency is published Biology Open! 🚀 Huge joint effort coming from PomboLab @BioComicsLab Sílvia Carvalho Prof Ana Pombo MDC-BIMSB UCIBIO Faculdade de Ciências e Tecnologia | NOVA FCT doi.org/10.1242/bio.06… ↓ Short thread below ↓

I am very pleased to share that our latest research🧑‍🔬 from PomboLab, about allele-specific chromatin structure 🧬, now live on bioRxiv. Shout out to Prof Ana Pombo, Alexander Kukalev, Rieke Kempfer and the rest of the team for this remarkable work of science. ↓ Short thread below ↓

What are the molecular effects of a single drug exposure 💉 on reward system #dopamine neurons 🧠? We found an unexpected role of 3D genome 🧬 structure in long-term cellular memory of a single #cocaine exposure. Dominik Szabó vedran franke Warren Winick-Ng Prof Ana Pombo MDC-BIMSB 1/6