Join us on 24 October at 12pm AEDT to hear about how patient registries are helping to accelerate clinical discoveries in MND research. Register at: fightmnd.org.au/fightmnd-scien…

Thank you to FightMND and all the supporters for giving a thumbs up to our new collaborative project Queensland Brain Institute, UQ with Adam Walker Dr. Samantha Barton Rebecca San Gil Carlie L Cullen Catherine Blizzard and co! We are eager to get started!

Want to deliver gene therapies broadly, but activate them only in diseased neurons? TDP-REG "hacks" TDP cryptic mis-splicing to drive expression only WHEN and WHERE needed! Less toxicity, wider therapeutic window, new options for sporadic ALS therapies. biorxiv.org/content/10.110…

Trends in Neurosciences 'Spotlight' by Matisse Jacobs, Rebecca San Gil & Adam Walker Walker Neuro Lab sciencedirect.com/science/articl… discussing Guo et al. 2023 ‘Disruption of ER ion homeostasis maintained by an ER anion channel CLCC1 contributes to ALS-like pathologies’ nature.com/articles/s4142…

A surprise from the lab now out in nature. The excellent Stephan Tetter set out to determine the #cryoEM structures of #FUS amyloid filaments in frontotemporal #dementia. Instead, he found abundant filaments of its homologue, TAF15! nature.com/articles/s4158…

Just out - Jane Simpson has a chat with Adam Walker about MND research and why there is cause for hope, on Jane's new podcast 'Let's Talk MND' open.spotify.com/episode/0vDUBZ…

Congratulations to Elise Kellett, who received the Joan Lawrence Endowment Prize for High Achieving Women in Neuroscience. 💜 Elise is currently doing her #PhD in the Walker Neuro Lab at the Queensland Brain Institute, UQ, researching potential therapeutic interventions in Motor Neuron Disease.

Congrats Elise Kellett - doing the lab proud!

Kicking goals Elise Kellett!

World-renowned scientist Dr. Virginia Man-Yee Lee at Penn Medicine has made groundbreaking contributions to our understanding of tau, earning her the 2024 #RainwaterPrize for Outstanding Innovation in Neurodegenerative Research, to be awarded at #Tau2024. rainwatercharitablefoundation.org/?p=1551

"We found several proteins that were driving disease forward and making it worse... we also found proteins that are increased early in disease and are protective." Queensland Brain Institute, UQ researcher Rebecca San Gil explains how her protein map could offer therapeutic pathways for #MND.

Trikafta — a triple small molecule combo therapy — can be considered functionally curative, though variant specific top-ups are still in play. More of this please!

This is sad news on the outcomes of the pivotal phase 3 trial of AMX0035, which did not meet any of the primary or secondary outcome measures for people living with ALS/MND. Next steps unclear, but there are many more treatments in testing which will hopefully be more positive.

SAVE THE DATE! We will be holding the 3rd Australian and New Zealand MND Research Symposium in Melbourne on Tuesday 27th and Wednesday 28th of August. An MND Connect session will also run on the Wednesday. Further information to come as we progress with the event.

Excellent piece on frontotemporal dementia by Amy Brodtmann.

Today would have been Justin's 50th birthday, but as many of you know, Justin passed away last year after a long battle with MND This weekend the Yerbury lab are taking part in the walk to defeat MND to raise vital funds to support those living with MND ⬇️ walktodefeatmnd.org.au/fundraisers/Na…

38 years ago a woman in Coventry sent a letter to some scientists. That letter went on to be the most important in Alzheimer's research. Last year, I met Carol Jennings, who wrote it. 1/ thetimes.co.uk/article/e78c47…

The @dehorterlab is excited to share a new study demonstrating a causal link between #immune activation, #alphasynuclein and #Parkinson onset. This work establishes the first immune-induced model to investigate the prodromal phase of idiopathic #Parkinson. Queensland Brain Institute, UQ John Curtin School of Medical Research, ANU