Woohoo! We are ecstatic to share our latest work "Mapping glycan-mediated galectin-3 interactions by live cell proximity labeling." Grateful to reviewers who provided feedback, even in a pandemic. #glycotime Eugene Joeh Weichao Li Chris Parker pnas.org/content/early/…

How postdoc set up a reaction

Thrilled to share my first publication as a first author! It's out! It's exciting! Glycans! 🔺🟦🟢🟡 Scripps Research Graduate Program Scripps Research #glycotime pubs.acs.org/doi/10.1021/ac…

Online ACS Catalysis Reports first #ascorbylatedalkaloids #enzyme in #securinegaalkaloids biosynthesis. We reveal the key intermediate in the biosynthesis of C-2 and C-3 functionalized derivatives of #Securinega alkaloids #firstcorrespondingauthorpaper pubs.acs.org/doi/10.1021/ac…

Check out our newest work on using chemoproteomic platform to exploring unexpected folate-interacting/binding proteins and reveals folate-modulated growth and development in Arabidopsis. Collaborate with fantastic people from CAAS and UGhent Ghent University Research. The Plant Cell

The final version of this work is now out in J. Am. Chem. Soc.. A big congrats to Wesley, Anny and team! pubs.acs.org/doi/10.1021/ja…

Happy to share our (w/ Teijaro Lab) integrated chemoprotoemic approach to develop functional inhibitors of SLC15A4 - a challenging target that controls some exciting biology

Big congrats to Junchen and Baran Lab on this feat! Excited to be able to contribute w/Weichao Li to this story. A great example of how enabling total synthesis can be to reveal new and exciting biology.

Humbled to be among this amazing cadre of scientists! Grateful for awesome team members Scripps Research that are eager to make an impact on #glycotime! Thank you also to a village of mentors and letter writers. #SloanFellow

The final version of this study was published today in nature : nature.com/articles/s4158…

Excited for this scripps Chem collaborative work out in nature w/Baran Lab & Lairson Lab. Has a bit of something for everyone…herculean total synthesis, structural reassignment, chemoproteomics, new druggable target, in-depth functional characterization & more

nature.com/articles/s4158… Delighted to share our recent work. We developed an enhanced chemoproteomic workflow to determine PAL probe interaction sites in cells, enabling ID of diverse binding pockets, providing evidence of their chemical tractability & more w/ForliLab & Bristol Myers Squibb

A new Nature Chemical Biology study, led by Chris Parker alongside Jacob M. Wozniak and Weichao Li, created a high-resolution technique for finding new druggable sites for any human disease, from cancer to Alzheimer’s disease. More at: ow.ly/9NLN50Qnb7x

Excited to share the final version in Nature Chemical Biology. Lots more mechanistic insights & characterization, including our inhibitors disrupt PPIs with mTOR components & induce lysosomal degradation of SLC15A4, & more. A promising target for autoimmune conditions. nature.com/articles/s4158…

Proteins are dynamic. These dynamics animate life.

Excited to share a new preprint from the lab. We show that PTMs like phosphorylation & glycosylation dynamically reshape proteome-wide ligandability in cells, including proteins like KRAS. Great collaboration with ForliLab, Mia Huang 黃雪兒 & Bristol Myers Squibb. biorxiv.org/content/10.110…

Thrilled to collaborate with these groups and show how N-linked glycosylation influences the binding of small molecules to the proteome! #glycotime