(1/n) Excited to share preprint by Viraat Goel Miles Huseyin We develop Region-Capture Micro-C (RCMC) By focusing on specific regions, we generate the deepest 3D genome maps thus far We see coalescence of enhancer and promoters into “microcompartments” biorxiv.org/content/10.110…

Thrilled to share that my first research paper is now published! 3D genomics has struggled to cost-effectively resolve fine-scale enhancer-promoter interactions; RCMC overcomes this bottleneck. Extremely grateful to Miles Huseyin & Anders Sejr Hansen for their support & guidance.

New preprint with Cerda-Smith, Hutchinson, Eyler, Wood et. al combining high-res Region Capture Micro-C (RCMC) with CRISPRa screens to identify functional enhancers of tumor supressor, PTEN, revealing separation between structural and functional elements: biorxiv.org/content/10.110…

Interesting new from Corri Sept Martin Aryee et al. combines MNase HiChIP for CTCF with new FactorFinder algorithm to profile 3D interactions conditional on CTCF being bound. Nice insights in loop extrusion from the perspective of CTCF-anchored cohesin biorxiv.org/content/10.110…

(1/2) New paper from KL Kim Gilbert J. Rahme (He/him/his) Brad Bernstein Gene Regulation Observatory with RCMC contribution from Viraat Goel ASHansen Lab sciencedirect.com/science/articl… Quantitative dissection of how loss of a CTCF insulator boundary in GIST causes aberrant enhancer-oncogene interactions