Are you interested how #epistasis shapes the AMR evolution?

We showed that epistasis can be caused by independently modulating substrate binding and the chemical step ultimately changing the rate-limiting step in the catalytic cycle. Nature Catalysis

nature.com/articles/s4192…

instagram.com/p/C2zJprvt0eV/…

🚨 Preprint alert 🚨

The first work from my lab where we expose the Achilles’ heel of beta-lactamase-producing enterobacteria is now out!!

Great effort led by CHerencias & Laura Álvaro Llorente in close collaboration with my friend Alvaro San Millan!!

Check the details below!! 👇

Interested in leading our laboratory activities, join fieldwork and research cruises, take part of developing UiTGenetics UiT Norges arktiske universitet and have good command of a Scandinavian language?
Then apply for this permanent position: jobbnorge.no/ledige-stillin…

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Great read and important work by Theresa Wagner CANS - Centre for New Antibacterial Strategies

Well deserved Chris and host🤩 It’s an awesome project. Really looking forward to follow it!

Great work Javier with crew!! Important and interesting research in this paper.

Our paper on the evolution of β-LACTAMASE-mediated CEFIDEROCOL resistance is out now in JAC:

*β-lactamases contribute to OR have the evolutionary potential to confer CFD resistance

*resulting in cross-resistance against CAZ (OXA-48) and CAZ-AVI (KPC-2)

academic.oup.com/jac/advance-ar…

Ørjan Samuelsen Pål Jarle Johnsen Vidar Sørum Tokuriki lab

Check our latest paper out now in mBio journals.asm.org/doi/10.1128/mb…

Excited to announce that our paper on the effects of Genetic Dominance in AMR Evolution has received one of the Microbiología Molecular SEM prizes from the Spanish Society of Microbiology SEM!! 🥳

Congrats to all fantastic coauthors macarena toll-riera Rafael Peña-Miller Vidar Sørum Alvaro San Millan!!

After more than six years working on this project, we can finally provide examples of how plasmid-mediated AMR evolves, not in a test tube, but in the gut microbiota of patients. Great team effort led by @Jav_DelaFuente biorxiv.org/content/10.110…

It’s already been a week since Vidar Sørum presented our work on the evolution of #cefiderocol resistance at #ECCMID2022 . Thanks for all the fantastic discussions and feedback, looking forward to next year.

⁦Christopher Frøhlich 🇪🇺🇳🇴🇨🇦🇩🇪🏳️‍🌈⁩ killed it with our second presentation of the day on our data on Oxa-48 evolution at ⁦ECCMID⁩ 22

Our own ⁦Jónína Sæunn Guðmundsdóttir⁩ presenting our latest data on cancer drugs potentially driving AMR- not surprisingly, she did an excellent job!!

That was amazing!!!

We studied the effect of β-lactamase expression on CEFIDEROCOL resistance development:

*they can contribute to cefiderocol resistance
*they are evolvable to further cefiderocol resistance
*evolution causes cross-resistance

Check out our new preprint:
biorxiv.org/content/10.110…

In a new research article from the MicroPop group, published in the December issue of @EBioMedicine, the authors show that the chemotherapeutic drug methotrexate selects for antibiotic resistance Jónína Sæunn Guðmundsdóttir Pål Jarle Johnsen Ørjan Samuelsen

sciencedirect.com/science/articl…

Our latest publication DTD Tromso on 'Biofilm Responsive Zwitterionic Antimicrobial Nanoparticles to Treat Cutaneous Infection' is available online on Biomacromolecules. Special thanks to our master student, Anna Ngoc Phung and to all our collaborators. pubs.acs.org/doi/10.1021/ac…

The chemotherapeutic drug methotrexate selects for antibiotic resistance: our most resent research, available online today in @EBioMedicine 🧫

In this paper we show the the widely used chemotherapeutic drug methotrexate selects for #AMR - a thread 1/5!

sciencedirect.com/science/articl…