Please RT! Registration is now open for the 7th Ubiquitin&Friends Symposium, which will be on 14-15 May in Vienna ub-friends.at/symposium/ Amazing lineup, great location, and most importantly friendly atmosphere. Hope you can join us!!!

Structure of RNA-dependent RNA polymerase from 2019-nCoV, a major antiviral drug target biorxiv.org/cgi/content/sh…

Fancy a break from Covid-19? Check out our latest work on interaction mapping of ER-resident ubiquitin ligases online now as a preprint in BioRxiv. We found a complex formed with RNF26 that modulates the cGAS-STING pathway and innate immune signalling. biorxiv.org/content/10.110…

Proud to present our lab's newest story: a collaboration between Nick Bodnar and @yipcjm92 in Susan Shao. The protein Ddi1 proteolyzes polyubiquitinated substrates, making it the only endoprotease other than the proteasome with such activty. pnas.org/content/early/…

Wish to thank the #CoV2 Team in my lab who volunteers to carry on the critical research on #coronavirus around the clock Monday till Sunday. Despite most of the research activities in our University being down this #science can not be stopped ✌️👍 IBC2

Really exciting!! Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved α-ketoamide inhibitors | Science science.sciencemag.org/content/early/…

An interesting pre-print by the Tobias Walther, 華濤北 lab. Used SILAC to assay global protein stability and identified new physiological substrates of ERAD. #ubiquitin #proteomics #proteinqualitycontrol doi.org/10.1101/2020.0…

Congratulations to Donghyuk on the first crystals of CoV2 protease. Such a good feeling and highly promising. #Science can deliver a lot in a short time when a small group of scientists (#CoV team) works closely together (most of the lab is shut down). 🙌😀👏👨‍👩‍👦‍👦

Saying the words “stay healthy” emitted thousands of saliva droplets. A cloth mask reduced droplet emission down to background levels. #Coronavirus Could SARS-CoV-2 be transmitted via speech droplets? | medRxiv medrxiv.org/content/10.110…

High resolution CryoEM structures show a new regulatory subunit of yeast fatty acid synthase (FAS), structurally similar to mycobacteria FAS. Has potential for new tuberculosis therapeutics. Congrats to the Chari/Stark and Tittmann groups! @mpi_bpc doi.org/10.1016/j.cell…

A truly remarkable paper. Congrats to the Rapoport lab and everyone involved! Having personally spent the past five years eating, sleeping and dreaming about the Hrd1 complex, I'm fascinated to finally see it in its full glory.

Watching #coronavirus replication! #SARSCoV2 polymerase-RNA structure: basis to study potential #COVID19 drug #Remdesivir Team Hauke Hillen Goran Kokic Lucas Farnung Christian Dienemann Dimitry Tegunov @mpi_bpc Max Planck Society Preprint biorxiv.org/content/10.110… PR mpibpc.mpg.de/17275755/pr_20…

Now Cell - Human recombinant soluble #ACE2 (hrsACE2) reduces #SARSCoV2 viral load, suggesting #hrsACE2 can block early stage infection bit.ly/3cPPl4P For Cell Press #coronavirus research- cell.com/2019-nCOV #COVID19

Here is a simple animation of #coronavirus replication: NTPs enter from the right and are added to the growing RNA copy (red) of the #SARSCoV2 RNA genome (blue) by the viral polymerase. #COVID19 Preprint: biorxiv.org/content/10.110… Press release: mpibpc.mpg.de/17275755/pr_20…

In the latest issue: on-demand secretion of #inflammatory factors and protein cargoes lacking #secretion #signal sequences relies on #TMED10, a protein that oligomerizes to channel the cargoes into secretory #vesicles bit.ly/2YnREYY

A brief COVID respite: Structure of the human ER membrane protein complex. science.sciencemag.org/content/early/… A glimpse into the role of this crazy complex in membrane protein biosynthesis. Congratulations @TinoPleiner, Gio, Kurt, @aj_inglis, and Masami. Caltech

Cryo-EM structure at 1.25 angstrom from the Stark lab @mpi_bpc. #CryoEM biorxiv.org/content/10.110…

Our new paper on the ERAD E3 ubiquitin ligase Doa10 is out in eLife - the journal! Congratulations to Claudia Schmidt and the Stein lab @mpi_bpc!

New review covering the #hallmarks of #health, now online! bit.ly/3gZkxlr

👀 Sneak a peek at the deepest & sharpest infrared image of the early universe ever taken — all in a day’s work for the Webb telescope. (Literally, capturing it took less than a day!) This is Webb’s first image released as we begin to #UnfoldTheUniverse: nasa.gov/webbfirstimage…