Whenever I'm feeling a little out of it scientifically or think I need huge sample sizes to say anything meaningful, I often re-read Green et al, Science, 2010. It's a truly otherworldly paper and of course duly won the Nobel Prize. The supplement is just🔥science.org/doi/abs/10.112…

How did humans develop unique traits despite sharing nearly identical genomes with other primates like chimpanzees? Together with Han Yang (Han Yang), our new study on human accelerated regions (HARs) sheds light on this question @ nature.com/articles/s4158…. 1/12

Pleasure to co-edit this issue of Current Opinion on human genetic origins with Jason Stein with support from @ELS_Genetics : sciencedirect.com/special-issue/…

Want a to make genetic maps from sperm/pollen/gametes? Now there is an easy way, based on Hi-C sequencing. Thanks to Richard Durbin and Ed Green for the idea and a great group of co-authors for contributions.

Ready for the most powerful foundation model for medical images/videos? 🚨 Just dropped: MedSAM2 The next-gen foundation model for 3D medical image & video segmentation — built on top of SAM 2.1. • Project site: medsam2.github.io • Paper: arxiv.org/abs/2504.03600 Why

Incredibly proud that our paper on the #palaeoproteomics analysis of the Penghu mandible, led by ''ﾉ.bsky.social and in collaboration with Chun-Hsiang Chang, Enrico Cappellini and co, is out now in Science Magazine! doi.org/10.1126/scienc…

Thrilled to share that the first project from my PhD is now published in Science (Science Magazine)! 🎉 We studied the genetic architecture of and evolutionary constraints on the human pelvic form. Read more: science.org/doi/10.1126/sc…

Incredible! Dragon man is a Denisovan. Major congratulations Qiaomei Fu cell.com/cell/fulltext/…

Based on the new DNA evidence now from Harbin, as well as Xiahe, it's now almost certain that the samples in the yellow box are all Denisovan. It's very exciting that we finally get to study the morphology of these samples in light of their relationship to us and Neanderthals.

Our new paper on ancient DNA to address the spread of Uralic languages now out in @nature (we started working on this in 2018). Many interesting results, including a sample from ~16k years ago Yakutia that can be modeled as an unadmixed Native American. nature.com/articles/s4158…

Listening to RD talk about early days of genome sequencing is still amazing! thenakedscientists.com/articles/inter…

Huge congratulations to Adam Klivans, for renewing the NSF Institute for the Foundations of Machine Learning at UT Austin with intent to expand generative AI to protein engineering and clinical imaging. nsf.gov/news/nsf-annou…

Uh oh: deep learning models in genomics lose badly to very simple linear models. Could they have been over-hyped? (new paper by Simon Anders Constantin Ahlmann-Eltze (@const-ae.bsky.social) and Wolfgang Huber) nature.com/articles/s4159…

Safety first, always hold on to the handrail! Except for when there is a massive Sunda King Cobra lying along the top of the handrail 🌶️

Our latest blog recaps the 200th episode of The Genetics Podcast.🎉 From Eric Topol’s AI predictions to Sir Rory Collins’ vision for UK Biobank, these timeless insights highlight how early conversations helped shape today’s breakthroughs. Read the recap: eu1.hubs.ly/H0mqZ9k0

I'm excited to announce the first ever BioML Fellowship 🧬💰🧬 We at the biomlsociety have been working with Texas Biologics and NaturalSciences @ UT over the past few months to create a fellowship that helps PhD students at UT Austin become leaders in the emerging field of BioML

Want to make recombination maps from sperm/pollen/gametes? There is an easy way, based on Hi-C sequencing. Full details in the Hi-reComb paper now in Genetics: doi.org/10.1093/geneti… Thanks to Richard Durbin and Ed Green and a great group of co-authors for contributions.

Large pedigrees are all the rage in ancient dna these days but thus far they’ve been manually reconstructed. Edward C. Huang from my group built an automated reconstruction tool, please try it out! x.com/edwardhuangc/s…

This was an incredible endeavor by the bioml society at UT Austin x.com/kosonocky/stat…

Whole-genome doubling (WGD) occurs in ~30% of solid tumors and is linked to poor outcomes. Is it a one-time event or an ongoing mutational process? In our new nature paper now in print, we show WGD continuously shapes tumor evolution and immune evasion. nature.com/articles/s4158…