Want to learn more about #AI-based tools for measuring and analyzing animal behavior? U-M faculty members Bing Ye and Carrie Ferrario are offering a symposium to introduce LabyGym, a free software suite for researchers. Learn more and register: lsi.umich.edu/events/2024-08…

Schematic overview of the Mmp14 dermal fibroblast survival program. From a study by Sabeh, Weiss et al. UMLifeSciences identifying Mmp14 as a requisite cell survival factor that maintains dermal fibroblast viability in postnatal dermal tissues. hubs.la/Q02Gm3K20

The LSI Aspirnaut fellows have spent 6 weeks immersed in authentic, hands-on research in U-M labs. Today, this group of outstanding high schoolers presented the results of those efforts — and showed how much they've accomplished and grown as scientists this summer.

Want to pursue a postdoctoral fellowship intentionally designed to prepare innovative scientists for their independent careers? Be sure to complete your application for the 2024 cohort of Michigan Pioneer Fellows by 11:59 p.m. ET this Friday, Aug. 2: pioneerfellows.umich.edu

To expand access to our unique scientific cores, and broaden collaborations with LSI faculty, the LSI is offering a new sabbatical program for academic and industry researchers external to U-M. Applications are due Aug. 17. Learn more: lsi.umich.edu/science/progra…

New research from Jun Wu's lab in UMLifeSciences and UMPhysiology published in #PLOSBiology shows that the nicotinic cholinergic pathway in the liver protects against the development of fatty liver disease dx.plos.org/10.1371/journa…

In a new ACS Catalysis study, LSI researchers have visualized the final step of a biological assembly line that produces macrolide antibiotics. Their findings open the door to tinkering with the process to build better antibiotics. Read more: myumi.ch/jZjJg

Nature-Inspired Radical Pyridoxal-Mediated C–C Bond Formation | Journal of the American Chemical Society Narayan Lab @ UMich University of Michigan UMLifeSciences Michigan Chemistry #Radical #Pyridoxal #CCBond #Formation Total Synthesis and Methodology Highlights pubs.acs.org/doi/10.1021/ja…

Our new paper is finally out! We discovered that the human tumor suppressor protein Pdcd4 binds to the #mRNA entry channel in the 40S ribosomal subunit, where it blocks the eIF4F-independent role of eIF4A. #ribosome #CryoEM UMich RNA Center 〽️🧬 UMLifeSciences nature.com/articles/s4146…

Authors Jay Brito Querido and colleagues from MRC Laboratory of Molecular Biology; University of Michigan Medical School; UMLifeSciences; UC Davis report the structure of human Pdcd4 bound to the ribosome, revealing how it blocks translation. nature.com/articles/s4146…

Celebrating another successful year of summer research at the LSI!

In this Review, Roger Cone and colleagues discuss targeting the central #melanocortin system for the treatment of #metabolic disorders (£) go.nature.com/46rPzvA

A chiral N-to-S acyl transfer auxiliary that unites the desirable features of imides for asymmetric transformations with the synthetic versatility of thioesters. By Alan Healy & David H. Sherman et al. NYUAD Research UMLifeSciences Read the paper 👉 go.acs.org/asQ

Using a combination of #cryoEM and biochemical data, Jay Brito Querido and colleagues have shed light on the structure of a tumor suppressor protein that prevents cell growth, invasion and metastasis. Read more in Nature Communications: nature.com/articles/s4146…

TDP43 mislocalization and aggregation are the hallmarks of several neurodegenerative diseases. Especially #ALS, #FTD. We recapitulate the initial pathogenic events in iPSC-derived #neurons and show that TDP43 accumulates within autophagosomes and lysosomes. #insitu #cryoET 1/

And that's a wrap for today's LabGym symposium! After a morning of introduction, participants in today's event gained hands-on experience with this #AI-based software used to measure and analyze animal behavior.

All of the #UMChemBio students came together today for a fantastic day of science at their annual fall retreat.

Our newest #UMChemBio PhD and Master's students start their programs today! Welcome ho〽️e!

Our review paper is out and I am excited to share it! 😄 UMLifeSciences

Researchers in the Shyamal Mosalaganti lab have revealed the first high-resolution structure of a protein that plays a role in Mucopolysaccharidosis IIIC (MSP IIIC), a lethal disorder for which there is no approved therapy or cure. The findings, published in @elife, provide a