New paper alert: A pH-sensitive DNA origami nanoswitch with death receptor ligands demonstrates cytotoxicity in an acidic microenvironment, reducing breast cancer tumor growth with minimal on-target/off-tumor toxicity. nature.com/articles/s4156…

Engineering ionizable lipids for rapid biodegradation balances mRNA vaccine efficacy and tolerability biorxiv.org/cgi/content/sh… #bioRxiv

Excited to share our recent work, out now as a preprint! LNP-based vaccines cause a lot of inflammation. We describe a strategy to dampen this inflammation through ionizable lipid chemistry while maintaining vaccine efficacy. biorxiv.org/content/10.110…

When another lab asks for a reagent and you say no problem you can have some

Gerrit Cole in the World Series: 12.2 IP 1 ER Yankees go 0-2 in his starts despite those magnificent stats.

Prof. Leo Chou has been awarded $130K in funding from the Cancer Research Society to propel forward an ambitious project aiming to boost the effectiveness of cancer vaccines: lnkd.in/guVc6AWy

The 5 biology papers & areas of progress I found most impressive in 2024 (with video explainers for each!): 1/n

This is awesome Julia Bauman ! Always enjoy your summaries!

Excited to share our most recent work in ACS Nano led by Travis Douglas where we manipulate antigen spacing on DNA origami nanoparticles to control immune complex formation! Congrats Travis! pubs.acs.org/doi/10.1021/ac…

Researchers from the Institute of Biomedical Engineering (BME) at the University of Toronto have developed a new method to precisely control the structure and function of immune complexes (ICs) using DNA origami: discover.bme.utoronto.ca/engineering-sy…

Happy to share a study from our own Travis Douglas, with implications for vaccine design: nanoscale patterning of antigens controls assembly of synthetic immune complexes. Great job Travis.