MedTox Fellows: Prolonged topical exposure to which one of the following produces seizures? The Tox And The Hound Jerry Snow

MedTox Fellows: Chronic ingestion of which one of the following produces leukoencephalopathy? @toxandhound Jerry Snow

MedTox Fellows: Plant and Mushroom Association Quiz. Match the numbered plant or mushroom with a letter so that each letter is used only once. @toxandhound Jerry Snow

MedTox Fellows. 51 YOF ingested son's weight-lifting supplement. Lethargic. HR 121, BP 103/55, R 38, T 103.8 F. Na 147, Cl 113, K 3.4, CO2 7, art lactate 3.3 mEq/L pH 7.14 pCO2 19 pO2 148 (NC) Subtle clue on hand. What is Dx, & why lactate so low? @toxandhound Jerry Snow

MedTox Fellows: What genus of plant is really to flower in my front yard? What is the receptor that both meperidine and a toxin/drug from this plant share with regard to affinity? The Tox And The Hound Jerry Snow

MedTox Fellows: 13 YOM ingested "sleeping pills" after fight with parents. Suprapubic tenderness, dry axillae. Pupils normal. What might he have taken? The Tox And The Hound Jerry Snow

MedTox Fellows - an easy inhibitors of oxidative phosphorylation association quiz. Name the inhibitor associated with each lettered figure. The Tox And The Hound

MedTox Fellows: 39YOM shoveling white solid for hours – shirtless and looked like a snowman – collapsed. Coma, AGMA, HR 144, BP 97/42, T 108F, R 42. PA cath placed: wide AVO2 diff and O2 consumption 620 cc/min. What was he shoveling? The Tox And The Hound Jerry Snow

MedTox Fellows: We see angioedema, shock & rapid collapse after rattlesnake bites. Angioedema usually resolves in several hours with antivenom and epinephrine. This time it didn't, but responded to FFP. Read about the topic at toxandhound.com/toxhound/ff-ra… The Tox And The Hound Jerry Snow

Pinning this for a while just to see what happens

MedTox Fellows: Which one of the following substances blocks K+ channels to lengthen the action potential and produce seizures in overdose? @toxandhound Jerry Snow

This 1927 paper reports boots to be effective at preventing lower extremity rattlesnake bites. But I've seen at least two patients bitten through leather boots. So, still stay 30 feet distant. The Tox And The Hound biodiversitylibrary.org/item/204589#pa…

MedTox Fellows: 28 YOM seen drinking from container by police brought to ED. Awake but sleepy, no complaints. VS nl. Labs and urine drug screen shown. CXR & ECG normal. Differential Diagnosis? The Tox And The Hound Jerry Snow

MedTox Fellows: Got standards to add Xanomeline & Trospium to our mass spec library. Xanomeline, a newly approved antipsychotic, activates all muscarinic receptors. Which subtypes are thought to be beneficial for desired effect? Why is tropsium given with it? The Tox And The Hound

MedTox Fellows: Asked to consult on “difficult to treat” ICU pt. Early coronary stent thrombosis, poor response to ondansetron, & past rhabdomyolysis with 40 mg/d simvastatin. Some of us just choose bad parents. Which results explain above? The Tox And The Hound Jerry Snow

MedTox Fellows: 61 YOF with hx of irritable bowel syndrome presents with 3 weeks of progressive myoclonus, confusion, and now, seizures. Which one of the following is most likely cause? Name the agent described in each answer. The Tox And The Hound Jerry Snow

Anthony Pizon Evan Schwarz @nephrotox Diane Calello 😷💉😷💉 Maryann Amirshahi Peter Chai Emily K Stephanie Carreiro @CMeadenMD Journal of Medical Toxicology Michelle Ruha Lewis Nelson Jeanmarie Perrone MD Mark Mycyk Steve Aks Steve Curry The Tox And The Hound Timothy Wiegand, MD, FACMT, FAACT, DFASAM Toxicology Investigators Consortium (ToxIC) Kim Aldy @RachelCulbreth Alyssa Falise, PhD, MSPH

For an overview of hydrides, check out: toxandhound.com/toxhound/ff-me… toxandhound.com/toxhound/ff-ph… toxandhound.com/toxhound/ff-bo… The Tox And The Hound Jerry Snow

Fellows: here is a short clip of TiCl4 being used for smoke generation. reddit.com/r/Damnthatsint… Both TiCl4 and VCl4 are liquids. Med Tox Fellows: what is "butter of arsenic", and is it solid, liquid, or gas? The Tox And The Hound Jerry Snow

MedTox Fellows: Inhibitor matching quiz. Single best answer. INHIBITS: 1. human translation 2. human RNA polymerase II 3. human DHFR 4. protozoan DHFR 5. human DNA polymerase-gamma 6. bacterial DHFR 7. bacterial translation 8. bacterial RNA polymerase