📰 By analysing 47 million genetic changes in 2,658 tumours, a team led by our Peter Van Loo and EMBL-EBI has found that there can be genetic signs of cancer years earlier than we thought. ✏️ Alex Cagan | #pcawg | Read the full story ➡️ crick.ac.uk/news/2020-02-0…

Please join us for an afternoon of virtual talks on the 30th November starting at 12.30pm UK time: Somatic Evolution and Tumour Microenvironment Symposium 2020 crick.zoom.us/webinar/regist… 👌🙂

Excited to share our new work published in @nature today by @darlanminussi Peter Van Loo Hanghui Ye and Franziska michor on TNBC, in which we asked what happens after the initial burst of chromosome instability? nature.com/articles/s4158…

📰 Peter Van Loo, Maxime Tarabichi & the #PCAWG consortium have analysed tumours from over 2,600 patients. They found lots of genetic diversity in individual tumours, and confirmed that tumour evolution is driven by changes that benefit the cancer. Cell crick.ac.uk/news/2021-04-0…

CAMDAC: Copy number-Aware Methylation Deconvolution Analysis of Cancer live on GitHub at github.com/VanLoo-lab/CAM…! Run CAMDAC on tumour RRBS data & get tumour purity, allele-specific copy number and methylation rates free from normal contaminants. Preprint: tinyurl.com/y46zuvvw

Millions of extra mutations retrieved in the non-unique regions of cancer genomes!? In the coding sequence of known cancer genes? In immunoglobulin genes in lymphoid tumours? And members of intriguing gene families? So thrilled this is finally out: nature.com/articles/s4158… 🥲🙃

Tumor samples vary in purity and ploidy, both of which confound DNA methylation measures from bulk sequencing. We developed CAMDAC to clean up this signal. Here's our extended preprint with new insights from applying CAMDAC to TRACERx lung RRBS data: biorxiv.org/content/10.110…