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CP2 after some brutal gravel #transengland21

CP3 highest Inn in Britain #transengland21

CP4 - St Nicholas church #transengland21

CP5 robin hood's bay #transengland21

Finish 15:54. Brutal #transengland21

Final #transengland21 activity. TheRacingCollective Will be back for more in the future and try to have less mechanicals... strava.app.link/CdvlUQUOEgb

Pretty stoked to finish 4th overall (3rd male) in the British 24hr Cycling Time Trial National Championships Easily met my main goal of breaking the 55 year old Cambridge University record Taking a day to recover before training loads of new students on microfluidics this week!

Excited to share our recent work in Nano Letters investigating the electrostatic forces that stablize protein condensates! pubs.acs.org/doi/abs/10.102… Thanks to my amazing co-authors Georg Krainer, Jorge, Jerelle A Joseph, Rosana Collepardo and more for their hard work! KnowlesLab Cambridge

Super happy to have contributed to this fantastic piece of work investigating the underlying nucleation mechanisms in solutions of phase separating proteins! biorxiv.org/content/10.110…

More from knowleslab at #bps2022 in #SanFrancisco. Ewa Andrzejewska Greta Šneiderienė, Alyssa & Tim Welsh presenting posters on pre-fibrilliar protein #aggregates and single-molecules studies, oligomer-membrane interactions, microfluidic spray-deposition & #biomolecular condensates.

Check out our preprint discovering DNA-induced LLPS of antibodies based on surface patch driven non-specific interactions: biorxiv.org/content/10.110… Great work by Hannes Ausserwöger, Georg Krainer, Tim Welsh, Tomas, Matthias Schneider & Therese. Exciting collaboration with Novo Nordisk

En route to Heidelberg for the #EESPhaseSeparation conference. Only a few more countries to cross before Monday morning! Come find me all week if you want to chat condensates, microfluidics, or bikes!

While antibodies have a remarkable track record in therapeutics, achieving sufficient specificity remains an issue. A Review in Nature Reviews Chemistry discusses the physicochemistry of non-specificity and outlines future opportunities to improve protein binding. go.nature.com/3O8fK1y

A new method for determining the interaction strengths among compounds that form biomolecular condensates relies on measurements of just one solute in one phase. Read go.aps.org/3Guq7L6 Daoyuan Qian Tim Welsh Jonny Nixon-Abell Georg Krainer Thomas Michaels KnowlesLab Cambridge

Our paper on the digital sensing of protein:aptamer interactions is finally published! One platform shows the ability to sense everything from single proteins up to biomolecular condensates and exosomes, while elucidating many biophysical parameters. Congrats to all authors!

Check out the new DigitISA assay for sensing biomolecular complexes in solution! Well done Georg Krainer Kadi-Liis Saar Tim Welsh Magda Czekalska Raphaël P. B. Jacquat and colleagues from Owens, Alberti and Klenerman groups! nature.com/articles/s4146…

An amazing platform for ultrahigh throughput protein solubility screening! Check the paper: pubs.acs.org/doi/10.1021/ac… Well done Nadia, Tomas, Marc Oeller, Hannes Ausserwöger, Aviad, Tim Welsh , Rungzhang, Daoyuan Qian, Vendruscolo Lab, Sormanni lab and others!