Supramolecular catalysts (capsules, anion-π, …) compared for asymmetric autocatalysis, self-replication, and breaking of the Baldwin rules – @NCCR_MSE teamwork makes it possible TiefenbacherLab Université de Genève Faculty of Science | UNIGE @NCCR_ChemBio

We report the resorcin[4]arene capsule as an efficient catalyst for epoxide-opening ether cyclizations. A comparison with alternative catalysts revealed a unique, product selectivity. A great @NCCR_MSE collaboration with the group of Prof. Pierre Matile. …mistry-europe.onlinelibrary.wiley.com/doi/abs/10.100…

Bioinspired ether cyclizations within a (pi)-basic capsule compared to autocatalysis on (pi)-acidic surfaces and pnictogen-bonding catalysts (TiefenbacherLab The Matile Group UNIGE_en) #OpenAccess onlinelibrary.wiley.com/doi/10.1002/ch…

We report an optimized version of our previously published iminium-catalysed 1,4-reductions inside the resorcinarene capsule. The enantioselectivity was increased to >90% ee through the addition of alcohol additives. RSC Advances Royal Society of Chemistry pubs.rsc.org/en/content/art…

Thioderivatives of Resorcin[4]arene and Pyrogallol[4]arene: Are Thiols Tolerated in the Self-Assembly Process? A study in #OL on the influence of free thiols on self-assembly, disulfide chemistry, and catalysis. From TiefenbacherLab. Check it out: fal.cn/3hIQd

We Report the synthesis of new thioderivatives of Resorcin[4]arene and Pyrogallol[4]arene and a study of their properties with regard to self-assembly, disulfide chemistry, and Brønsted acid catalysis. J Org Chem/Org Lett ACS Publications pubs.acs.org/doi/10.1021/ac…

Congratulations Dr. Pham – outstanding discussion with TiefenbacherLab, wonderful to be back live, with hybrid participation from all over the world UniGE - Organic Chemistry Department Faculty of Science | UNIGE Université de Genève @NCCR_ChemBio @NCCR_MSE

We report the synthesis of Xanthene[n]arenes: Exceptionally large, bowl-shaped macrocycles suitable for the construction of cavitands, hydrogen-bonded capsules and hydrocarbon belts. JACS Au ACS Publications pubs.acs.org/doi/10.1021/ja…

We report that the resorcinarene capsule/HCl-catalyzed carbonyl olefin metathesis tolerates Lewis-basic protecting groups, in contrast to most alternative catalysts. pubs.acs.org/doi/10.1021/ac… J Org Chem/Org Lett ACS Publications

We report the first examples of optically active hexameric resorcin[4]arene capsules, which catalyze the enantioselective tail-to-head terpene cyclization of nerol with e.e. of up to 70%. Angewandte Chemie onlinelibrary.wiley.com/doi/10.1002/an…

We report a novel large deep-cavitand system, with unprecedented affinity for fullerenes and the ability to selectively bind C70 in the presence of C60.onlinelibrary.wiley.com/doi/10.1002/an…

Megalo-Cavitands: Synthesis of Acridane[4]arenes and Formation of Large, Deep Cavitands for Selective C70 Uptake by TiefenbacherLab #openaccess onlinelibrary.wiley.com/doi/10.1002/an…

Hyperresponsive expanding XL product space? Well then, never mind, @NCCR_MSE spirit at its best, amazing how these magic TiefenbacherLab capsules make new molecules, how pnictogen-bonding catalysis breaks the Baldwin rules. Thank you Chemical Science Université de Genève Faculty of Science | UNIGE

We have openings for a PhD and a postdoc position in supramolecular catalysis: Ph.D. position in Supramolecular Catalysis (jobs.unibas.ch/offene-stellen…); Postdoc position in Supramolecular Catalysis (jobs.unibas.ch/offene-stellen…).

Our recent work on the unusually large, conformationally restricted acridane[4]arenes and their application to megalo-cavitands made it to the ACS C&EN’s molecules of the year vote! Congratulations to Jonathan for his great work. cen.acs.org/synthesis/Chec…

We report the synthesis of four new supramolecular tweezer-based catalysts, capable of preferential C-H oxidation of strongly deactivated aliphatic positions. …mistry-europe.onlinelibrary.wiley.com/doi/10.1002/ch…

We report the resorcin[4]arene capsule-catalyzed synthesis of diverse, novel terpenoid frameworks which are inaccessible by natural enzymes. onlinelibrary.wiley.com/doi/10.1002/an…

We report highly β-selective furanosylation reactions enabled by the resorcin[4]arene capsule. In contrast to pyranosylation inside the same catalyst, the furanosylation mechanism is shifted towards SN1 on the continuum between SN1-SN2 substitution types. pubs.acs.org/doi/full/10.10…

We report a computational algorithm capable of predicting the outcome of complex carbocationic rearrangements, and employ it to encode complex terpene structures into much simpler precursors. Great collaboration with the Grzybowski and Burke groups nature nature.com/articles/s4158…

Our latest research is now published in JACS Au! 🎉We've developed a novel macrocycle that self-assembles into a catalytically active hexameric cage, capable of converting substrates too large for traditional resorcin[4]arene capsules pubs.acs.org/doi/10.1021/ja…