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Original: Drs. Hirsch, Birklein et al (Mainz University) found that TLR4 drives inflammation & pain after bone fractures, potentially triggering complex regional pain syndrome — ♂ mice lacking TLR4 showed less swelling & neuroimmunoinflammation Full: jpain.org/article/S1526-…

Original: Oliveira et al. (Universidade Aveiro) compared cognition & sarcopenia b/w older adults w/ & w/o pain — Groups similar for cognition, but older adults w/ pain showed ⬆ signs of sarcopenia — Partially explained by kinesiophobia & pain severity Full: jpain.org/article/S1526-…

Original: Waring, Abbie Jordan et al. (University of Bath) describe that people with CRPS experience unusual changes to bodily functions and sensations, with describing them as a malevolent force which robs them of their humanity Full: jpain.org/article/S1526-…

Original: Drs. Matthias, Hirsh & team (IU School of Medicine) led the EQUIPD pilot study, testing a coaching intervention to improve shared decision-making in Black patients with chronic pain & depression. —improvements in pain, depression, anxiety Full: jpain.org/article/S1526-…

Original: A study on temporal summation of second pain by Drs. Elley Wakui, Fidanza and Martini found that affective touch significantly reduced pain ratings and altered brain activity, suggesting parietal beta reduction as a potential biomarker. FREE: jpain.org/article/S1526-…

Featured: Drs. Sapio, Mannes et al. (NIH) established a simple white-light photobleaching method cuts background noise, boosting signal clarity in human CNS/PNS and disease tissue. FRE: jpain.org/article/S1526-…

Focus: Drs. Miller & Farrar describe a methodology for determining minimally clinically important differences using the double stopwatch technique, the gold standard for assessing meaningful changes in acute pain Full: jpain.org/article/S1526-…

Review: Wilson et al. (IIMPACT in Health, UniSA) demonstrate that many consumers value peer interaction and use comparison-based cognitive processing within group-delivered programs for chronic pain Full: jpain.org/article/S1526-…

Review: Drs. Tripathi, Kumar et al. reviewed rodent models to study intervertebral disc degeneration (IVDD), offering insights into inflammation, repair, and genetics. Full: jpain.org/article/S1526-…

Review: Toye, Karen Barker et al. (OUH) present themes, in poetic form, from a synthesis of 189 qualitative studies. — Science🤝Art — Inclusive arts-based research methods have potential to underpin compassionate pain care for young people FREE: jpain.org/article/S1526-…

Review: Drs. Perea, Liesbet De Baets, Jo Nijs at al. reviewed current screening tools to investigate obstructive sleep apnea in chronic musculoskeletal pain: — No consistent traits distinguish CMP patients with OSA — need for better diagnostics Full: jpain.org/article/S1526-…

Original: Dr. Sweekriti Sharma🇳🇵, Dr. Saurab Sharma (Saurab Sharma, PhD) et al. show that a quarter of adults are affected by low back pain in Nepal — Women and older people are more likely to experience back pain in Nepal Full: jpain.org/article/S1526-…

Original: Drs. Valdes-Hernandez, Yenisel Cruz-Almeida (she, her, hers) & coll. found that chronic pain may impair brain waste clearance via poor sleep. — In knee pain patients, widespread pain predicted reduced glymphatic function over 2 years, mediated by sleep issues. Full: jpain.org/article/S1526-…

Original: Drs. Sawada, Shinoda et al. showed that ADP activates P2Y12 receptors on satellite cells, boosting TNF-α release and neuron excitability in temporomandibular disorder — Blocking this pathway may offer new relief Full: jpain.org/article/S1526-…

Original: Dr. Hu, Yang et al. found that boosting Sema3A in sensory neurons reduces neuropathic pain by blocking PI3K/AKT/mTOR signaling and eIF2α phosphorylation, lowering ion channel expression Full: jpain.org/article/S1526-…

Original: Drs. Liu, Wong et al. Acceptance and Commitment Therapy combined with exercise improved pain, disability, mental health, and fitness in older adults with chronic low back pain. FREE: jpain.org/article/S1526-…

Original: Dr. Hedman-Lagerlöf et al. (Karolinska Institutet) present a cost-effectiveness evaluation of exposure-based vs. traditional CBT for fibromyalgia — May be a cost-effective alternative, but there appears no marked cost- or effect differences FREE: jpain.org/article/S1526-…

Original: Drs. Islas-Espinoza, Granados-Soto (Cinvestav) et. coll. found that cannabidiol relieves neuropathic pain and cognitive issues in female mice via spinal PPARγ and 5-HT1A receptors. Full: jpain.org/article/S1526-…

Original: Dr. van der Miesen et al. analyzed habituation, sensitization, & nocebo effects based on individual differences in response to painful stimulation — Large individual differences were observed Full: jpain.org/article/S1526-…

Original: Dr. Kim (UW–Madison), Dr. Shigemoto (FLORIDA) et al. highlight that post-traumatic growth (PTG) pathways differ across racial groups with chronic pain, shaped by sociocultural influences Full: jpain.org/article/S1526-…